Phycotoxins – Chemistry and Biochemistry 2e

Dr Luis M Botana is Director of the Community Reference Laboratory for Marine Toxins and Head of the Department of Pharmacology, University of Santiago de Compostela, Spain. Dr Amparo Alfonso is Professor of Pharmacology, University of Santiago de Compostela, Spain.

List of contributors vii Preface xiii 1 Analysis of marine toxins: gaps on food safety control of marine toxins 1 Paz Otero and Carmen Alfonso 2 Pharmacology of ciguatoxins 23 Carmen Vale, Alvaro Antelo and Victor Martin 3 Chemistry of pinnatoxins 49 Phillip Mabe and Armen Zakarian 4 Chemistry and analysis of PSP toxins 69 Ana Botana and Veronica Rey Lopez 5 Chemistry of palytoxin and its analogues 85 Patrizia Ciminiello, Carmela Dell Aversano and Martino Forino 6 Pharmacology of palytoxins and ostreocins 113 M. Carmen Louzao, Maria Fraga and Natalia Vilarin o 7 Recent insights into anatoxin-a chemical synthesis, biomolecular targets, mechanisms of action and LC-MS detection 137 Custodia Fonseca, Manuel Aureliano, Feras Abbas and Ambrose Furey 8 Therapeutics of marine toxins 181 Eva Alonso and Juan A. Rubiolo 9 Marine toxins as modulators of apoptosis 203 Amparo Alfonso, Andrea Fernandez-Araujo and Mercedes R. Vieytes 10 Cyanobacterial toxins 225 Vitor Vasconcelos, Pedro Leao and Alexandre Campos 11 Marine toxins and climate change: the case of PSP from cyanobacteria in coastal lagoons 239 Antonella Luglie, Silvia Pulina, Milena Bruno, Bachisio Mario Padedda, Cecilia Teodora Satta, and Nicola Sechi 12 Microalgae as a source of nutraceuticals 255 Sushanta Kumar Saha, Edward McHugh, Patrick Murray and Daniel J. Walsh 13 The marine origin of drugs 293 Andre Horta, Celso Alves, Susete Pinteus and Rui Pedrosa 14 Pharmacology of cylindrospermopsin 317 Juan A. Rubiolo, Diego Alberto Fernandez, Henar Lopez and M. Carmen Louzao 15 Pharmacology of the cyclic imines 343 Natalia Vilarino, Sara F. Ferreiro, Andres Crespo and Jose Gil 16 Diversity of organic structures of marine microbial origin with drug potential 361 Marcel Jaspars, Rainer Ebel and Hai Deng 17 Polyketides as a source of chemical diversity 381 Tanya Beletskaya, Catherine Collins and Patrick Murray 18 Ichthyotoxins 407 John W. La Claire II and Schonna R. Manning 19 Pathological clues of phycotoxin ingestion 463 Manuel Cifuentes, Andres Crespo and Roberto Bermudez Index 513