Principles of Genetics, Binder Ready Version

D. Peter Snustad is a Professor Emeritus at the University of Minnesota, Twin Cities. He received his B.S. degree at the University of Minnesota and his M.S. and Ph.D. degrees from the University of California, Davis. He began his faculty career in the Department of Agronomy and Plant Genetics at Minnesota in 1965, became a charter member of the new Department of Genetics in 1966, and moved to the Department of Plant Biology in 2000. During his 43 years at Minnesota, he taught courses ranging from general biology to biochemical genetics. His initial research focused on the interactions between bacteriophage T4 and its host, E. coli. In the 1980s , his research switched to the cytoskeleton of Arabidopis and the glutamine synthetase genes of corn. His honors include the Morse-Amoco and Dangley Memorial teaching awards and election to Fellow of the American Association for the Advancement of Science. A lifelong love of the Canadian wilderness has kept him in nearby Minnesota. Michael J. Simmons is a Professor in the Department of Genetics, Cell Biology and Development at the university of Minnesota, Twin Cities. He received his B.A. degree in biology from St. Vincent College in Latrobe, Pennsylvania, and his M.S. and Ph.D. degrees in genetics from the University of Wisconsin, Madison. Dr. Simmons has taught a variety of courses, including genetics and population genetics. He has also mentored many students on research projects in his laboratory. Early in his career he received the Morse- Amoco teaching award from the University of Minnesota in recognition of his contributions to undergraduate education. Dr. Simmon's research focuses on the genetic significance of transposable elements in the genome of Drosophilia melanogaster. He has served on advisory committees at the National Institutes of Health and was a member of the Editorial Board of the journal Genetics for 21 years. One of his favorite activities, figure skating, is especially compatible with the Minnesota climate.

CHAPTER 1 The Science of Genetics 1 CHAPTER 2 Celluar Reproduction 18

CHAPTER 3 Mendelism: The Basic Principles of Inheritance 40

CHAPTER 4 Extentions of Mendelism 62

CHAPTER 5 The Chromosomal Basis of Mendelism 89

CHAPTER 6 Variation in Chromosome Number and Structure 110

CHAPTER 7 Linkage, Crossing Over, and Chromosome Mapping in Eukaryotes 135

CHAPTER 8 The Genetics of Bacteria and Their Viruses 163

CHAPTER 9 DNA and the Molecular S tructure of Chromosomes 192

CHAPTER 10 Replication of DNA and Chromosomes 220

CHAPTER 11 Transciption and RNA Processing 256

CHAPTER 12 Translation and Genetic Code 285

CHAPTER 13 Mutation, DNA Repair, and Recombination 320

CHAPTER 14 The Techniques of Molecular Genetics 366

CHAPTER 15 Genomics 397

CHAPTER 16 Applications of Molecular Genetics 439

CHAPTER 17 Transposable Genetic Elements 477

CHAPTER 18 Regulation of Gene Expression in Prokaryotes 504

CHAPTER 19 Regulation of Gene Expression in Eukaryotes 531

CHAPTER 20 The Genetic Control of Animal Development 558

CHAPTER 21 The Genetic Basis of Cancer 581

CHAPTER 22 Inheritance of Complex Traits 607

CHAPTER 23 Population Genetics 634

CHAPTER 24 Evolutionary Genetics 656

Appendices

Appendix A: The Rules of Probability 685

Appendix B: Binomial Probabilities 687

Appendix C: In Situ Hybridization

Appendix D: Evidence for an Unstable Messenger RNA 691

Appendix E: Evolutionary Rates 693

Answers to Odd-Numbered Questions and Problems 697

Glossary 720

Photo Credits 743

Illustration Credits 745

Index 746