New Developments in Calcium Signaling Research

Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG, is Adjunct Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA (2013 - ). Dr. Yamaguchi is engaged in the fields of endocrinology and cell signaling since 1971, and these researches are developed in the aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer cell bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001). Dr Yamaguchi generated regucalcin transgenic rats, which were registered as international patents including USA, EU and Japan, and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis. Thus far, Dr Yamaguchi published over 550 English articles to professional journals with peer-review, and registered over 20 national and international patents.

Preface; The 1, 25 Dihydroxyvitamin D3-Membrane-Associated, Rapid Response Steroid-Binding Receptor: Physiological Roles & Characterization of Binding Partners; Modulation of Airway Epithelial Cell Calcium & Airway Hydration in Cystic Fibrosis: Role of Glucocorticoids & Lipoxins; ExcitationTranscription Coupling: A Quantitative Approach; A Novel Concept on the Repetitive Calcium Elevation; Calcium-Binding Proteins in the Liver Fluke, Fasciola hepatica; Role of Regucalcin in Calcium Signaling of Kidney Cells; Suppressive Role of Regucalcin in Cell Protein Synthesis: Involvement in Calcium Signaling; Index.