Proteases in Health and Disease (eBook)

Dr. Sajal Chakraborti is a Senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant- and calcium-signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 35 years.Dr. Naranjan Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 40 years.

Part A: Molecular and Biochemical Aspects of Proteases.- 1. An Overview of Endoplasmic Reticulum Calpain System.- 2. Mitochondrial Calpains: Who, What, Where, When and Why?.- 3. Role of Calpains in Calmodulin Regulated Systems.- 4. Exercise and Matrix Metalloproteases: A Brief Overview.- 5. Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression.- 6. Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential.- 7. Aspartic Proteolytic Inhibitors Induce Cellular and Biochemical Alterations in Fungal Cells.- 8. Cysteine Proteases of Human Malaria Parasites.- 9. Proteases as Virulence Factors in Leishmania: Focus on Serine Proteases as Possible Therapeutic Targets.- 10. An Updated Inventory on Properties, Pathophysiology and Therapeutic Potential of Snake Venom Thrombin-like Proteases.- 11. Macrocyclic Protease Inhibitors Constrained into a β-Strand Geometry.- Part B: Involvement of Proteases in Disease Processes.- 12. Regulation of MT1-MMP Activation and Its Relevance to Disease Processes.- 13. Role of Proteases During Intra-erythrocytic Developmental Cycle of Human Malaria Parasite Plasmodium falciparum.- 14. Proteases in Vibrio cholerae and Their Role in Pathogenesis.- 15. ADAMTS13: The von Willebrand Factor Cleaving Protease and Its Role in Thrombotic Thrombocytopenic Purpura.- 16. Role of Proteases and Their Tissue Inhibitors in Pregnancy Outcome.- 17. Matrix Metalloproteinases in Bone Health and Disease.- 18. Escalated Expression of Matrix Metalloproteinases in Osteoarthritis.- 19. Role of Proteases in Autism Spectrum Disorder.- 20. Role of Proteases in the Management of Hepatitis C Virus.- 21. Role of Protease in Inflammatory Lung Diseases.- 22. Involvement of Some Proteolytic Enzymes in Cardiac Dysfunction Due to Ischemia-Reperfusion Injury.