Anion-Induced Enantioselective Cyclization Catalyzed by Cationic Gold Catalysts
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In this thesis the first highly enantioselective functionalization of terminal alkynes using gold(I) catalysts incorporating optically active counteranions is described.
Cationic gold(I) catalysis was used in a novel asymmetric synthesis of substituted pyrrolidines, 2,3-dihydro-1H-pyrroles, and tetrahydrofurans from 1,4-diynamides, 1,6- diynamides, and 1,4-diynols, respectively. The role of counteranions in these transformations was studied and their employment found to be crucial for high selectivities. Utilizing the newly-developed catalytic system allows an access to the products in near quantitative yields and in good to excellent enantiomeric excesses.
Cationic gold(I) catalysis was used in a novel asymmetric synthesis of substituted pyrrolidines, 2,3-dihydro-1H-pyrroles, and tetrahydrofurans from 1,4-diynamides, 1,6- diynamides, and 1,4-diynols, respectively. The role of counteranions in these transformations was studied and their employment found to be crucial for high selectivities. Utilizing the newly-developed catalytic system allows an access to the products in near quantitative yields and in good to excellent enantiomeric excesses.
Zusatzinfo | zahlr. farb. Abb. |
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Verlagsort | Berlin |
Sprache | englisch |
Maße | 148 x 210 mm |
Einbandart | Paperback |
Themenwelt | Naturwissenschaften ► Chemie ► Anorganische Chemie |
Schlagworte | Enantioselective Cyclization • Gold • Katalysator |
ISBN-10 | 3-89574-846-3 / 3895748463 |
ISBN-13 | 978-3-89574-846-2 / 9783895748462 |
Zustand | Neuware |
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