Oncogene and Transgenics Correlates of Cancer Risk Assessments

Cancer Risk Assessments: An Overview.- Pharmacodynamic Models for Cancer Risk Assessment.- Predictive Value for Cancer Risk Assessment of Cell-and Tissue-Specific Formation of Carcinogen-DNA Adducts.- Studies on the Role of Protein Kinase C in Multistage Carcinogenesis and Their Relevance to Risk Extrapolation.- Oncogene Activation and Human Cancer.- Genetics of Hepatocarcinogenesis in Mouse and Man.- Protein Kinase C in Carcinogenesis: Comparative Expression of Oncogenes and Protein Kinase C in Rhabdomyosarcoma Models.- Oncogenes and Human Cancers.- ‘In Vivo’ Model Systems to Study ras Oncogene Involvement in Carcinogenesis.- K-ras Oncogene Activation in Neoplasias of Patients with Familial Adenomatous Polyposis or Kidney Transplant.- An Overview of Transgenic Mice as Future Models of Human Diseases, In Drug Development, And for Genotoxicity and Carcinogenesis Studies.- Regulating Gene Expression in Mammalian Cell Culture and Transgenic Mice with Yeast Gal4/Uas Control Elements.- Genes and Oncogenes of the ras Superfamily.- Oncogenic Transgenic Mice in the Study of Carcinogenesis.- Leukemia, Lymphoma, Embryonic Carcinoma and Hepatoma Induced in Transgenic Rabbits by the c-myc Oncogene Fused with Immunoglobulin Enhancers.- An Overview of the Outstanding Issues in the Risk Assessment of Methylene Chloride.- Cancer Dose-Response Modeling and Methylene Chloride.- Risk Assessments for Benzene-Induced Leukemia — A Review.- Comparative Metabolism and Genotoxicity Data on Benzene: Their Role in Cancer Risk Assessment.- Dose-Response Relationships for Benzene: Human and Experimental Carcinogenicity Data.- A Threshold for Benzene Leukemogenesis.- Some Points for Discussion from the Oncogene Workshop.- Concluding Remarks, Findings and Recommendations.