Cancer Biology and the Nuclear Envelope

Eric C. Schirmer, Ph.D., Wellcome Trust Senior Research Fellow, Wellcome Trust Centre for Cell Biology and Reader, Institute of Cell Biology at the University of Edinburgh. Jose de las Heras Ph.D., Researcher at the University of Edinburgh.

Section I: History and use of the nuclear envelope in cancer prognosis: Overview and perspective.- Cancer and the nuclear envelope, a history and perspective.- The role of the nuclear lamina in cancer and apoptosis.- The diagnostic pathology of the nuclear envelope in human cancers.- Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer.- "To be or not to be in good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer.- Section II: The nuclear envelope in cell cycle regulation and signaling.- pRb and lamins in cell cycle regulation and aging.- Lamina-associated polypeptide (LAP)2a and other LEM proteins in cancer biology.- NETs and cell cycle regulation.- Nuclear envelope regulation of signaling cascades.- Section III: Nuclear envelope regulation of the genome.- Nuclear envelope - connecting structural genome organization to regulation of gene expression.- Studying lamins in invertebrate models.- Lamin organization of chromosome positioning.- Section IV: Functions of the NPC in cancer.- NPC proteins linked in cancer overview.- Roles of the nucleoporin Tpr in cancer and aging.- Ran GTPase in nuclear envelope formation and cancer metastasis.- Wnt signaling proteins associate with the nuclear pore complex: implications for cancer.- Section V: The nuclear envelope in DNA damage and stress responses.- DNA damage and lamins.- Repo-Man at the intersection of chromatin remodeling, DNA repair, nuclear envelope organization and cancer progression.- Lamines and oxygen stress damage in cell proliferation.- Section VI: The nuclear envelope link to cell migration and metastasis.- Nuclear mechanics in cancer.- Nuclear envelope in nuclear positioning and cell migration.- Nesprins in cell stability and migration.- Connecting the nucleus to the cytoskeleton for nuclear positioning and call migration.- Section VII: Towards a molecular explanation of prognostic links to the nuclear envelope.-Nuclear envelope invaginations and cancer.- Mechanisms of nuclear size regulation in model systems and cancer.- Control of nuclear size by NPC proteins.- Do lamins influence disease progression in cancer?.