Apoptosis and the Immune System

A review of the current understanding of apoptosis, which discusses its role in the deletion of self-reactive lymphocytes, the prevention of autoimmunity, the death of T cells infected by the HIV virus, termination of the immune system, neoplasia and regulation of the haematopoietic system.

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Apoptosis and the Immune Response

Edited by Christopher D. Gregory

In this timely and important work, an international group ofleading investigators takes a close and critical look at programmedcell death and its role in the development, function, andmaintenance of the immune system. Along with covering the primaryactions of apoptosis, the contributors probe its role incarcinogenesis and HIV-induced pathogenesis. By offering a broadrange of views, Apoptosis and the Immune Response presents acurrent and complete picture of the various aspects andconsequences of this phenomenon.

Apoptosis and the Immune Response begins with the theoriessurrounding apoptosis and then covers its basic mechanismsincluding the morphologic, biochemical, and genetic features. Thebook offers authoritative discussions on the role of apoptosis inthe deletion of self-reactive lymphocytes, prevention ofautoimmunity, termination of the immune response, death of T cellsinfected by the HIV virus, neoplasia, and the homeostaticregulation of the hematopoietic system.

In particular, this excellent reference critiques such topics as:
* Apoptosis in thymocytes in vivo and in vitro
* Bcl-2/T-cell transgenics
* The role of c-myc
* Fas/APO-1 antigens and their roles
* Transgenic models of B-cell tolerance and autoimmunity
* How apoptosis affects the pathogenesis of AIDS and theimplications for therapy
* Triggers for apoptosis and survival
* Recognition of apoptotic cells by phagocytes
* Apoptosis in peritoneal autoreactive CD5+ B cells
* and more

With its diverse expertise and timely, clear-cut insights,Apoptosis and the Immune Response will prove to be an invaluableresource for immunologists, cell and developmental biologists,hematologists, and oncologists--as well as graduate students.

Cover Design: Janice Noto-Helmers