Chemical Mutagens

1 In Vivo Mutagenicity Testing Using Somatic Cells of Drosophila melanogaster.- 1. Introduction.- 2. Basic Developmental Biology of Drosophila.- 3. The Wing Mosaic System.- 4. The White/White-Coral Eye Mosaic System.- 5. The Unstable White-Zeste Eye Mosaic System.- 6. Exposure Techniques.- 7. Discussion.- 8. Conclusions.- 9. References.- 2 Structural and Metabolic Parameters Governing the Mutagenicity of Polycyclic Aromatic Hydrocarbons.- 1. Introduction.- 2. Activation Pathways of PAHs.- 3. Contribution of Different Activation Pathways to the Mutagenicity of PAHs.- 4. Metabolic Control of Mutagenic Intermediates of PAHs.- 5. Summary and Conclusions.- 6. Addendum: Recent Developments.- 7. References.- 3 Chromosomal Mutations: The Genetic Approach.- 1. Introduction.- 2. The Main Categories of Chromosomal Mutation.- 3. Genetic Detection of Aneuploidy in the Mouse.- 4. Reciprocal Translocations: Detection and Analysis.- 5. Detection and Study of Other Translocations and of Inversions.- 6. Detection and Study of Deletions.- 7. Conclusions.- 8. References.- 4 Cytogenetic Assays for Mitotic Poisons Using Somatic Animal Cells.- 1. Introduction.- 2. Mitotic Poisons and Their Genomic Effects.- 3. Assays with Diploid Mammalian Cells in Vitro.- 4. Assays with Bone Marrow Cells in Vivo.- 5. Assays with Grasshopper Embryos.- 6. Conclusions.- 7. References.- 5 Detection of Aneuploidy in Drosophila.- 1. Introduction.- 2. Issues.- 3. Assay Systems.- 4. Known Positives.- 5. Summary.- 6. References.- 6 Mammalian Cytogenetic and Genetic Tests for Nondisjunction.- 1. Introduction.- 2. Cytogenetic Tests.- 3. Genetic Test Systems with the Mouse.- 4. Summary and Conclusions.- 5. References.- 7 Using Repair-Deficient Chinese Hamster Ovary Cells to Study Mutagenesis.- 1. Introduction.- 2. Genetic and Biochemical Properties of Repair-Deficient Mutants.- 3. Hypersensitivity of Repair Mutants to DNA-Damaging Agents.- 4. Rapid Detection of DNA-Damaging Agents by Differential Cytotoxicity (DC).- 5. Conclusions.- 6. References.- 8 Transplacental Genotoxic Agents: Cytogenetic Methods for Their Detection.- 1. Introduction.- 2. Animal Studies.- 3. Human Studies.- 4. References.- 9 Computer Automation of Metaphase Finding, Sister Chromatid Exchange, and Chromosome Damage Analysis.- 1. Introduction.- 2. Historical Trends in Computer Automation.- 3. Development of a System for Cytogenetic Mutagenicity Testing.- 4. Future Prospects for Full Automation.- 5. References.- 10 Mutagen-Sensitive Mutants and Chemical Mutagenesis in Drosaphila.- 1. Introduction.- 2. Isolation and Localization of Mutants.- 3. Biochemical Characteristics.- 4. Larval Exposure.- 5. Adult Exposure.- 6. Maternal Effects.- 7. Storage Effect.- 8. Conclusions.- 9. References.- 11 Chromosomal Causes for Fertility Reduction in Mammals.- 1. Introduction.- 2. Numerical Chromosome Mutations of the Sex Chromosomes and Related Conditions.- 3. Structural Chromosome Anomalies.- 4. Combinations of Chromosome Mutants within One Carrier.- 5. Viable Unbalanced Progeny Obtained from Translocation Heterozygote Females and Males.- 6. Why is Chromosomal Infertility More Clearly Expressed in the Male Than in the Female? Consideration of X-Autosome Translocations.- 7. References.- 12 Mutagenesis and Plasmids.- 1. Introduction.- 2. Historical Overview of Plasmids.- 3. Survey of Thirty-Three R Plasmids.- 4. Mechanisms of Plasmid-Mediated Effects on Mutagenesis and Survival.- 5. References.- 13 Mutation in Somatic Cells as Determined by Electrophoretic Analysis of Mutagen-Exposed Chinese Hamster Ovary Cells.- 1. Introduction.-3. Results and Discussion.- 4. Summary.- 5. References.