Inflammatory Diseases and Copper - John R. J. Sorenson

Inflammatory Diseases and Copper

The Metabolic and Therapeutic Roles of Copper and Other Essential Metalloelements in Humans
Buch | Softcover
622 Seiten
2011 | Softcover reprint of the original 1st ed. 1982
Humana Press Inc. (Verlag)
978-1-4612-5831-5 (ISBN)
213,99 inkl. MwSt
In 1928, it was discovered that copper was essential for normal human metabolism. A decade later, in 1938, it was observed that patients with rheu­ matoid arthritis exhibited a higher than normal serum copper concentration that returned to normal with remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic dis­ eases. The first report that copper complexes had antiinflammatory activity in an animal model of inflammation appeared twenty-two years after the dis­ covery of essentiality. In 1976, it was suggested that the active forms of the antiarthritic drugs are their copper complexes formed in vivo. This sugges­ tion has been confirmed and extended in the interim in over 200 recent publications. Individual biomedical scientists from many countries who have published in these areas recently saw a need for a meeting to exchange current re­ supporting new hypotheses. We search results and discuss the evidence met on the University of Arkansas Medical Sciences campus in Little Rock, Arkansas, August 10-13, 1981. Participants came from Australia, England, France, Germany, Israel, Italy, The Netherlands, Norway, Poland, Scotland, Sweden, Switzerland, Wales, Zimbabwe, and over twenty of the United States.

Physiological Aspects of Copper Metabolism.- Copper Homeostasis.- Estrogen Modulation of Blood Copper and Other Essential Metal Concentrations.- The Role of Leukocyte Endogeneous Mediator (Endogenous Pyrogen) in Inflammation.- Computer Analysis of Low Molecular Weight Copper Complexes in Biofluids.- Ceruloplasmin: Experimental Antiinflammatory Activity and Physicochemical Properties.- Physiological Aspects of Copper Metabolism.- Wilson’s Disease.- Copper Metabolism in Menkes’ Syndrome and in Mottled Mouse Mutants.- Intestinal Content of the Copper-Binding Protein in Brindled, Blotchy and Crinkled Mice and Cellular Copper Transport.- Teratogenic Effects of Copper Deficiency and Excess.- An Appraisal of Current Human Copper Nutriture.- Environmental Metal Ion Perturbations, Especially as They Affect Copper Status, Are a Factor in the Etiology of Arthritic Conditions: An Hypothesis.- Biochemical Aspects of Copper Metabolism.- Hormonal Regulation of Copper and Zinc Metabolism in Isolated Rat Liver Parenchymal Cells.- Ceruloplasmin: A Multi-Functional Cupro-Protein of Vertebrate Plasma.- Comparison of the Catalytic Activities of Mammalian Ceruloplasmins.- Lysyl Oxidase, A Molecular Target of Copper.- Cu-Zn Superoxide Dismutase.- The Carboxylation of Preprothrombin.- Biological Aspects of Copper Metabolism in Inflammation.- The Effect of Ceruloplasmin and Iron on the L-Ascorbic Acid-Induced Depolymerization of Hyaluronic Acid.- Copper, Free Radicals, and Rheumatoid Arthritis.- Hepatic Adaptation Process During Inflammatory Conditions: Role of Trace Elements, Lipid Peroxidation, and Ceruloplasmin.- Roles of Superoxide in Inflammation and Ischemic Shock.- The Metabolism of Gold: Possible Mechanisms for Perturbations of Copper and Zinc Homeostasis.- AntiinflammatoryActivities of Copper Complexes.- Copper Complexes as the Active Metabolites of the Antiinflammatory Agents.- Comparison of the Antiinflammatory Activities of Copper Complexes in Different Models of the Inflammation.- The Copper Problem and Amino Acids.- Copper and Inflammation.- Antiinflammatory Properties of Implanted Copper.- Antiulcer, Antimicrobial, and Anticancer Activities of Copper Complexes.- The Antiulcer Activities of Copper Complexes.- Development and Therapeutic Actions of Oral Copper Complexes of Anti-Inflammatory Drugs.- Antimycoplasmal Approach to the Mechanism and the Control of Rheumatoid Disease.- The Antimycoplasmal Activity of Copper Bipyridyl Complexes.- Antitumor Activities of Compounds with Superoxide Dismutase Activity.- Therapy of Rheumatic Diseases.- Copper-Salicylate in Rheumatoid Arthritis and Similar Degenerative Diseases.- Therapy of Inflammatory Diseases with Superoxide Dismutase.- The Results of a Copper Bracelet Clinical Trial and Subsequent Studies.- Treatment of Rheumatoid Arthritis with Zinc Sulfate.- Immunomodulation Imposed by Chronic Treatment with D-Penicillamine and Zinc in the Mouse.- Possible Mechanisms of Action.- Reactivity of Chelated Copper with Superoxide.- Molecular Mechanism of Zinc Action, and a Note on the Treatment of SLE in the Mouse with Zinc.- Stabilization of Gamma Globulin with Copper Complexes: Possible Relevance to the Etiology of Rheumatoid Arthritis.- In Vitro Studies of Anti-Inflammatory Copper Complexes: Some Difficulties in Their Chemical Interpretation.- Mechanisms of Action of Metal Ions on Hepatocytes.- Modulation of Lymphocyte Function by Copper and Thiols.- Poster Presentations.- Immunological Consequences of Copper Deficiency in Mice.- Selenium in Rheumatoid Arthrtis and Liver Cirrhosis.- Influenceof Oral Zinc Intake on Whole Blood and Plasma Levels of Copper.- The Influence of Pancreatic Secretions on Copper Metabolism.- Effect of Dietary Copper on Adjuvant Arthritis in the Rat.- The Influence of Thiols on Superoxide Dismutase Activity in Erythrocytes.- Leucocyte Superoxide Dismutase in Rheumatoid Arthritis.

Erscheint lt. Verlag 21.11.2011
Reihe/Serie Experimental Biology and Medicine ; 2
Zusatzinfo XXI, 622 p.
Verlagsort Totowa, NJ
Sprache englisch
Maße 155 x 235 mm
Themenwelt Sachbuch/Ratgeber Natur / Technik Garten
Naturwissenschaften Biologie Biochemie
ISBN-10 1-4612-5831-6 / 1461258316
ISBN-13 978-1-4612-5831-5 / 9781461258315
Zustand Neuware
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