Animals in Biomedical Research

Acknowledgements. Contributors. Addresses of Authors. Preface (Ian F.H. Purhase) 1. Animal Experimentation and the Concept of Alternatives (Coenraad F.M. Hendriksen). 2. Current Guidelines and Regulations in Toxicology Research (Herman B.W.M. Koeter). 3. Long-Term Policy in Toxicology (Marcel Roberfroid). 4. The use of Animals in the Production and Quality Control of Biologicals: Current Practice and Possible Alternatives (Coenraad F.M. Hendriksen). 5. Production of Biological Products and the Use of Laboratory Animals (E. Joost Ruitenberg and Peter C. van Mourik). 6. Basic Research in Physiology and Pharmacology, Some Introductory Remarks (Karl J. Obrink). 7. An Overview of the Role of In Vivo and In Vitro Testing in Physiology and Pharmacology (Carol L. Meschter, Guy Mazue and Gary H. Williams). 8. Neurotransmission: Automated In-Vitro Assays (Cor J. de Vos, Anton M.L. van Delft, Thijs de Boer, Ge S.F. Ruight and Joop S. de Graaf). 9. The Role of Animal Experiments and Alternatives in Industrial Pharmacological Research (Rian de Jonge, Jan H. Reinders and Wim J. Pereboom). 10. Experimental Animal Reduction in Connection with Pharmacopoeial Requirements for Pharmaceuticals (Feddo C. Hillen). 11. Education and Animal Experimentation (Bert F.M. van Zutphen). 12. The use of Animals in Veterinary Training (Andrew N. Rowan). 13. Nutritional Factors in Animal Experimentation (Anton C. Beynen). 14. The Role of Animal Husbandry in Promoting Welfare of Laboratory Animals (Ellen P. Reese). 15. The Reduction of Animal Use Through Genetic Control of Laboratory Animals (Michael F.W. Festing). 16. Prevention and Relief of Pain and Distress (Paul A. Flecknell). 17. Clinical Assessment of Pain, Distress and Discomfort (P.H.M. Griffiths). 18. Discomfort and Distress in Rodents During Chronic Studies (Marga H.M. Kuijpers and H.C. Walvoort). 19. Assessment of Distress Through Pathological Examination (Henk C. Walvoort). 20. The Effect of Alternative Methods on the use of Animals in Biomedical Research (Coenraad F.M. Hendriksen). 21. Perspectives (Herman B.W.M. Koeter and Coenraad F.M. Hendriksen).