Modulators, Mediators, and Specifiers in Brain Function

Section I Mechanisms of Neuronal Communication.- Three Modes of Communication in the Nervous System.- Do Behaviorally Active Polypeptide Hormones Act at Crucial “Command” Sites or at Many Sites, from “Command” Down to “Final Common Paths”?.- Neurotransmitters and Neuromodulators and their Mediation by Cyclic Nucleotides.- Metabolism Factors Affecting Grain Cyclic Nucleotides.- Phosphoproteins as Specifiers for Mediators and Modulators in Neuronal Function.- Phosphoproteins as Proposed Modulators of Visual Function.- Evidence for the Presence of Substrates for cGMP Dependent Protein Phosphorylation in Human Synaptosomal Membranes.- Section II Interactions of Neuropeptides, Cyclic Nucleotides and Phosphoproteins in Mechanisms Underlying Receptor Function.- Regulation of Central Adrenergic Receptors.- Regulation of the Neuroblastoma X Glioma Hybrid Opiate Receptors by Na+ and Guanine Nucleotides.- Phosphorylation of the Acetylcholine Receptor.- The Behaviorally Active Neuropeptide ACTH as Neurohormone and Neuromodulator: The Role of Cyclic Nucleotides and Membrane Phosphoproteins.- Opioid Peptides as Modulators of Cyclic AMP Levels.- Opioid Peptides and Protein Phosphorylation.- Section III Clinical Implications.- Adaptive Alterations in Receptor Mediated Processes and Their Implications for some Mental Disorders.- Endorphins and Clinical Pain, An Overview.- The Obesity of Middle Age: A Common Variety of Cushing’s Syndrome due to a Chronic Increase in Adrenocorticotrophin (ACTH) and Beta- Endorphin Activity.- Hormonal and Other Effects of Naltrexone in Normal Men.- Measurement of ß-Endorphin-Like Immunoreactivity in CSF and Plasma of Neuropsychiatric Patients.