Viral Cytopathology

1 Cytopathic Effects of Viruses: A General Survey.- 1. Defining the Problem.- 2. Historical Background.- 3. Viral Cytopathology: General Principles.- 4. Specific Cytopathic Viruses: An Overview.- 5. Some Subcellular Targets of Pathogenic Viruses.- 6. Summary.- 7. References.- 2 Transcription by RNA Polymerase II.- 1. Introduction.- 2. Polymerase II Control Regions: In Vivo.- 3. Polymerase II Promoters: In Vitro.- 4. RNA Polymerase II and Factors.- 5. Closing Comments.- 6. References.- 3 Regulation of Eukaryotic Translation.- 1. Introduction.- 2. The Rate-Limiting Step in Translation.- 3. Functional Domains in Messenger RNA.- 4. Initiation of Translation.- 5. Role of Initiation Factors in Binding of mRNA.- 6. Translational Control by mRNA Competition.- 7. Translational Control by Regulation of eIF-2 Activity.- 8. Translational Regulation by Other Means.- 9. Parameters Determining Translational Efficiency of an mRNA Species.- 10. References.- 4 Picornavirus Inhibition of Host Cell Protein Synthesis.- 1. Introduction and Scope.- 2. Properties of Inhibition of Host Cell Protein Synthesis by Poliovirus.- 3. Proposed Models for Inhibition.- 4. Initiation Factors.- 5. Cap Recognition Activity.- 6. Polioviral Mediator of Host Cell Shut-off.- 7. Other Picornaviruses.- 8. Other Viruses That May Utilize Mechanisms Similar to Poliovirus.- 9. Concluding Remarks.- 10. References.- 5 Rhabdovirus Cytopathology: Effects on Cellular Macromolecular Synthesis.- 1. Introduction.- 2. Properties of Rhabdoviruses: A Brief Survey.- 3. Cellular Responses to Rhabdovirus Infection.- 4. Protein Synthesis Inhibition by Vesicular Stomatitis Virus.- 5. VSV Inhibition of Cellular Nucleic Acid Synthesis.- 6. Summary.- 7. References.- 6 Adenovirus Cytopathology.- 1. Introduction.- 2.Adenovirus—Mammalian Cell Interactions.- 3. Effects of Adenovirus Infection on Cellular DNA Metabolism.- 4. Cellular RNA Metabolism in Adenovirus-Infected Cells.- 5. Selective Translation of Viral mRNA in Productively-Infected Cells.- 6. Summary and Conclusions.- 7. References.- 7 The Effects of Herpesviruses on Cellular Macromolecular Synthesis.- 1. Introduction.- 2. Early Studies.- 3. Effects on DNA Synthesis.- 4. Effects on RNA Synthesis.- 5. Effects on Protein Synthesis.- 6. Other Herpesviruses.- 7. Mechanisms.- 8. Conclusion.- 9. References.- 8 Poxvirus Cytopathogenicity: Effects on Cellular Macromolecular Synthesis.- 1. Introduction.- 2. Poxvirus Cytopathogenicity.- 3. Concluding Remarks.- 4. References.- 9 Reovirus Cytopathology: Effects on Cellular Macromolecular Synthesis and the Cytoskeleton.- 1. Introduction.- 2. Reovirus Effects on Host Cell DNA Synthesis.- 3. Reovirus Effects on Host Cell RNA and Protein Synthesis.- 4. Reovirus Effects on Cytoskeletal Organization.- 5. Summary.- 6. References.- 10 Inhibition of Host Cell Macromolecular Synthesis following Togavirus Infection.- 1. Introduction.- 2. Acute Infection by Alphaviruses in Vertebrate Cell Cultures.- 3. Chronic and Persistent Infection by Alphaviruses in Vertebrate Cell Cultures.- 4. Infections by Flaviviruses in Vertebrate Cell Cultures.- 5. Infection by Togaviruses in Invertebrate Cell Cultures.- 6. Concluding Remarks.- 7. References.- Cumulative Contents.- Cumulative Author Index.- Cumulative Subject Index.