Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

Section I: Insulin-Like Growth Factors I and II.- Structural and regulatory aspects of the human genes encoding IGF-I and-II.- Structural and functional characterization of IGF-I RNA 3’ variants.- Characterization of the biological activity of IGF I analogs with reduced affinity for IGF receptors and binding proteins.- Insulin-like growth factor II: Complexity of biosynthesis and receptor binding.- Development of a specific radioimmuno assay for E domain containing forms of insulin-like growth factor II.- The role of the IGFs in myogenic differentiation.- Extinction of human insulin-like growth factor II expression in somatic cell hybrids.- The growth hormone-insulin-like growth factor I axis: Studies in man during growth.- Recombinant human insulin-like growth factor I: Effects in normal subjects and implications for use in patients.- Single sc administration of insulin-like growth factor I (IGF-I) in normal men.- Section II: Insulin-Like Growth Factor Binding Proteins.- Insulin-like growth factor binding protein control secretion and mechanisms of action.- Regulation and actions of insulin-like growth factor binding protein-3.- Regulation of gene expression of rat insulin-like growth factor binding proteins 1 and 2.- Hormonal regulation of insulin-like growth factor binding protein-1 expression in the rat.- Cerebrospinal IGF binding proteins: Isolation and characterization.- The effect of quantity and nutritional quality of dietary proteins on plasma concentration of nsulin-like growth factor binding proteins (IGFBP) and the saturability of IGFBP with endogenous IGF-I.- Presence of insulin-like growth factors and their binding protein in rat milk.- Section III: Receptors For Insulin, IGF-I AND.- Molecular heterogeneity of insulin receptors in rat tissues.- Mutationsin the insulin receptor gene in patients with genetic syndromes of insulin resistance.- Role of receptor internalization in insulin signalling.- Endogenous substrates of the insulin receptor: Studies with cells expressing wild-type and mutant receptors.- Molecular mechanisms involved in the antilipolytic action of insulin: Phosphorylation and activation of a particulate adipocyte cAMP phosphodiesterase.- Regulation of the glucose transporter in animal models of diabetes.- Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states.- IGF-I mediated recruitment of glucose transporters from intracellular membranes to plasma membranes in L6 muscle cells.- Insulin-like growth factors and their receptors in muscle development.- Insulin-like growth factor receptors in testicular vascular tissue from normal and diabetic rats.- Reciprocal modulation of binding of lysosomal enzymes and insulin-like growth factor-ll (IGF-II) to the mannose 6-phosphate/IGF-ll receptor.- Expression of IGF-II, the IGF-ll/mannose-6-phosphate receptor and IGFBP-2 during rat embryogenesis.- Section IV: Insulin, IGFs and The Central Nervous System.- Early events in the hormonal regulation of glial gene expression: Early response genes.- Trophic actions of IGF-I, IGF-II and insulin on cholinergic and dopaminergic brain neurons.- Second messengers mediating gene expression essential to neurite formation directed by insulin and insulin-like growth factors.- Regulation of protein phosphorylation by insulin and insulin-like growth factors in cultured fetal neurons.- A review of insulin/insulin-like peptide in the central nervous system.- Glucose transporters in central nervous system glucose homeostasis.- The mammalian brain glucose transport system.- Regulation andphysiological function of insulin-like growth factors in the central nervous system.- IGF-I mRNA localization in trigeminal and sympathetic nerve target zones during rat embryonic development.- Neuroactive products of IGF-1 and IGF-2 gene expression in the CNS.- Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice.- Localization of insulin and Type 1 IGF receptors in rat brains by in vitro autoradiography and in situhybridization.- Insulin-like growth factor binding proteins in the nervous system.- Binding of 125 l-insulin-like growth factor-l (IGF-I) in brains of Alzheimer’s and alcoholic patients.- IGF-I - A possible modulator of intercellular communication in the brain.- Contributors.