Mechanisms of Anesthetic Action in Skeletal, Cardiac, and Smooth Muscle

I — Skeletal Muscle.- 1. Skeletal Muscle Targets for the Action of Anesthetic Agents.- 2. Effects of Lipid-Soluble Agents on Sodium Channel Function in Normal and MH-Susceptible Skeletal Muscle Cultures.- 3. Effect of Halothane on Human Skeletal Muscle Sarcoplasmic Reticulum Calcium-Release Channel.- 4. Ca Release from Skeletal Muscle SR: Effects of Volatile Anesthetics.- 5. Halothane-Cooling Contractures and Regulation of the Myoplasmic Ca2+ Concentration in Skeletal Muscle.- 6. Interactions of Fatty Acids with the Calcium Release Channel in Malignant Hyperthermia.- Transitional Concepts (Skeletal ? Cardiac Muscle).- 7. Why Does Halothane Relax Cardiac Muscle but Contract Malignant Hyperthermic Skeletal Muscle?.- II — Cardiac Muscle.- 8. Cardiac Effects of Anesthetics.- 9. Effects of Volatile Anesthetics on the Intracellular Calcium Transient and Calcium Current in Cardiac Muscle Cells.- 10. Halothane Inhibits Binding of Calcium Channel Blockers to Cardiac Sarcolemma.- 11. Contribution of the Known Subcellular Effects of Anesthetics to Their Negative Inotropic Effect in Intact Myocardium.- 12. Effect of Volatile Anesthetics on Intracellular Ca2+ Concentration in Cardiac Muscle Cells.- 13. Effects of Volatile Anesthetics on Cardiac Sarcoplasmic Reticulum as Determined in Intact Cells.- 14. Alcohol and Anesthetic Actions on Myocardial Contractility: Evidence for a Lipophilic/Electrophilic Sarcoplasmic Reticulum Site.- 15. Volatile Anesthetics and Second Messengers in Cardiac Tissue.- 16. The Effects of Volatile Anesthetics on the Calcium Sensitivity of Cardiac Myofilaments.- 17. Evidence for a Halothane-Induced Reduction in Maximal Calcium-Activated Force in Mammalian Myocardium.- 18. Mechanisms of Negative Inotropy of Halothane, Enflurane and Isoflurane inIsolated Mammalian Ventricular Muscle.- III — Smooth Muscle.- 19. Anesthetic Effects on Vascular Smooth Muscle.- 20. Endothelium-Derived Relaxing Factor (EDRF): Production from L-Arginine.- 21. Effect of Volatile Anesthetic Agents on Endothelium-Dependent Relaxation.- 22. Cerebral Vascular Responses to Anesthetics.- 23. Interactions of Volatile Anesthetics and Reactive Oxygen Intermediates on Vascular Smooth Muscle.- 24. Isoflurane-, Halothane- and Agonist-Evoked Responses in Pig Coronary Arteries and Vascular Smooth Muscle Cells.- 25. Mechanisms of Action of Anesthetics on Inositol Phospholipid Hydrolysis in Vascular Endothelial Cells and Rat Basophilic Leukemia Cells in Tissue Culture.- 26. Direct Actions of Volatile Anesthetics on the Coronary Vasculature.- 27. Effects of the Volatile Anesthetics on the Coronary Circulation in Chronically Instrumented Dogs.- Contributors.