Contributions of Physiology to the Understanding of Diabetes

Ten Essays in Memory of Albert E. Renold

Gaston R. Zahnd, Claes B. Wollheim (Herausgeber)

Buch | Softcover

XV, 173 Seiten

2013 | 1. Softcover reprint of the original 1st ed. 1997
Springer Berlin (Verlag)
978-3-642-64422-1 (ISBN)

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Recent developments in research on diabetes mellitus embrace basic disciplines such as physiology, biochemistry, morphology and evolving sub-specialities. Fundamental studies on the heterogeneous diabetic syndrome are oriented towards regulatory principles of cell metabolism, genetic control mechanisms of insulin biosynthesis and secretion, as well as autoimmune events implicated in selective destruction of pancreatic ß-cell. In parallel, efforts are made for a better understanding of normal versus impaired biological actions, both of insulin and insulin-like growth factor I, and the translocation process of glucose transporters in insulin-responsive target cells.

Thoughts on the Regulation of Adenylyl Cyclase Systems by Hormone-Sensitive G-Proteins: A Tribute to Albert E. Renold.- Anabolic Response to Cell Swelling in the Liver.- Intercellular Communication and Insulin Secretion.- Expression of the Insulin Gene and Its Regulation.- Implications of the Glucokinase Glucose Sensor Paradigm for Pancreatic ?-Cell Function.- How Ca2+ and Other Signalling Pathways Control the Exocytosis of Insulin in the ?-Cell.- The Mechanism of Insulin Receptor Binding, Activation and Signal Transduction.- Cell Biology of Insulin Action on Glucose Transport: Looking Back.- Insulin-like Growth Factor: Endocrine and Autocrine/Paracrine Implications and Relations to Diabetes Mellitus.- On the Pathogenesis of Insulin-Dependent Diabetes Mellitus in Man: A Paradigm in Transition.- Selected References from the Bibliography of Albert E. Renold, M.D.

Erscheint lt. Verlag	3.10.2013
Zusatzinfo	XV, 173 p. 35 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	299 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	biochemistry • Biology • Cell Biology • Cells • Diabetes • Diabetes mellitus • Growth factor • Insulin • insulin-like • Insulin Secretion • Metabolic disease • Metabolism • Physiology • Protein • signaling pathways • signal transduction
ISBN-10	3-642-64422-8 / 3642644228
ISBN-13	978-3-642-64422-1 / 9783642644221
Zustand	Neuware