Comprehensive Virology

Vol 15: Virus-Host Interactions Immunity to Viruses

Buch | Softcover

294 Seiten

2011 | Softcover reprint of the original 1st ed. 1979
Springer-Verlag New York Inc.
978-1-4613-3011-0 (ISBN)

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The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, bio chemical cytology, and high resolution microscopy and spec troscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.

1 Immune Responses, Immune Tolerance, and Viruses.- 1. Introduction.- 2. Immune System.- 3. Immune Responses in Nonviral Systems.- 4. Immune Responses in Viral Systems.- 5. Immune Tolerance in Viral Systems.- 6. Conclusion.- 7. References.- 2 Interaction of Viruses with Neutralizing Antibodies.- 1. Introduction.- 2. Methods.- 3. Antibody.- 4. Antigen-Antibody Interaction.- 5. Neutralization.- 6. Viral Neutralization.- 7. The Nonneutralized Fraction (NNF).- 8. Neutralization by Antibody Fragments.- 9. Virolysis.- 10. Mechanisms.- 11. General Concluding Comments.- 12. References.- 3 Humoral Immunity to Viruses.- 1.Introduction.- 2. The Complement System.- 3. General Considerations of Virus Structure and Interactions with Humoral Elements.- 4. Nonimmune Non-Complement-Related Humoral Viral Neutralizing Factors.- 5. Antibody-Dependent Viral Neutralization.- 6. General Features of Antibody- and Complement-Dependent Viral Neutralization.- 7. Antibody- and Complement-Dependent Viral Neutralization: Nonlytic Mechanisms.- 8. Antibody- and Complement-Dependent Viral Neutralization: Lytic Mechanisms.- 9. Nonimmune Complement-Dependent Viral Inactivation.- 10. Conclusions.- 11. References.- 4 Cellular Immune Response to Viruses and the Biological Role of Polymorphic Major Transplantation Antigens.- 1. Introduction.- 2. Cellular Immunity and the Major Histocompatibility Gene Complex.- 3. Antigens Involved in Immune Recognition: Viral Antigens and Self Antigens Coded by the Major Histocompatibility Gene Complex.- 4. MHC Restriction and Immune Responsiveness.- 5. Polymorphism of MHC Products and MHC-Linked Susceptibility to Disease.- 6. References.- 5 Interferons.- 1. Introduction.- 2. Interferon Synthesis.- 3. Mechanisms of the Antiviral Activity.- 4. Molecular Characterization of Interferons.- 5. Interaction with the Immune System.- 6. Antitumor and Cell Multiplication Inhibitory Effects.- Type II Interferon.- 8. Summary and Conclusions.- 9. References.

Reihe/Serie	Comprehensive Virology ; 15
Zusatzinfo	XVI, 294 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
ISBN-10	1-4613-3011-4 / 1461330114
ISBN-13	978-1-4613-3011-0 / 9781461330110
Zustand	Neuware