Trace Elements in Clinical Medicine

Raulin Award Lecture.- Discovery of Human Zinc Deficiency and Marginal Deficiency of Zinc.- Neural Disorders.- Zinc in Taste and Smell Disorders.- Brain Aging and Trace Elements in Human: Clues into the Pathogenesis of Alzheimer’s Disease.- Zinc in Brain Development and Function.- Zinc Binding Peptides from Rat Brain.- Role of Zinc in the Peripheral Nervous System.- Cardiovascular Disorders.- Experimental and Epidemiological Studies on the Relation of Trace Elements in the Pathogenesis and Prevention of Cardiovascular Diseases.- Hepatic and Gastrointestinal Disorders.- Alcohol, Trace Elements, and Liver Dysfunction.- Regional Variations of Eight Trace Elements in Normal Human Liver.- The Role of Copper and Zinc as Pathogenic Factors in Liver Disease.- Zinc and Gastrointestinal Diseases.- Pathophysiological Significance of an Oral Zinc Tolerance Test in Patients with Chronic Hepatic Diseases.- Zinc Absorption in Normal Subjects and in Gastrointestinal Diseases.- The Relationship Between Plasma Iron Tolerance Curves and Fractional Intestinal Absorption of Iron.- Regulators of Iron Absorption in the Small Intestine.- Dialysis and Renal Disorders.- Aluminum Intoxication.- Search for the Unknown Trace Element Abnormalities in Uremia.- Neoplasma.- Selenium and Cancer.- Kinetics of Trace Elements in Cancer Patients.- Trace Elements in Cancer Diagnosis.- Trace Elements in Cancer Therapy.- Immunity.- Modulation of the Immune Response by Trace Elements.- Trace Element Regulation of Immunity and Infection.- Zinc and Thymulin.- Stress.- Effects of Exercise, Physical Trauma, and High Sugar Intake on Chromium, Copper, and Zinc Metabolism.- Zinc: The Role and It’s Implication in Clinical Surgery.- Total Parenteral Nutrition.- Trace Elements in Total Parenteral Nutrition.- Effectof Zinc Redistribution on Wound Healing during Total Parenteral Nutrition in Rats.- Clinical Study on Zinc Deficiency Receiving Total Parenteral Nutrition.- Molecular and Biochemical Aspects of Selenium Deficiency.- Platelet Glutathione Peroxidase Activity in Long-term Total Parenteral Nutrition with/without Selenium Supplementation.- Cardiomyopathy and Selenium Deficiency in a Caucasian Adolescent.- Drugs and Trace Elements.- Nephrotoxicities of Gold and Cisplatinum.- Drug-Induced Taste Disorder: Due to Zinc Chelation?.- Antiarthritic, Antiulcer, and Analgesic Activities of Copper Complexes.- Genetic Disorders.- Genetic Disorders of Copper Transport: Menkes’ Disease , Occipital Horn Syndrome, and Wilson’s Disease.- Prevention Possibility for Brain Dysfunction in Menkes’ Disease by Maternal Administration of Trace Elements.- Human and Canine Inherited Copper Toxicosis: Copper Balance Regulation and Molecular Genetics of Its Impairment.- Gene.- Finger-Loop Domains and Trace Metals.- Construction of Mouse Glutathione Peroxidase Gene and Its Expression.- The Role of Natural Opal Suppressor tRNA in Incorporation of Selenium into Glutathione Peroxidase.- Transcriptional Activation of Human and Yeast Metallothionein Genes by Heavy Metal Ions.- The Problems of Nutritional Requirement of Trace Elements.- Recommended Dietary Intakes of Trace Elements: Some Observations on Their Definition and Interpretation in Comparison with Actual Levels of Dietary Intake.- The Problems of Nutrition Requirements of Trace Elements: General Comments.- Trace Element Requirements and Dietary Intake Recommendations: With Specific Reference to the Third World.- Biochemical Characterization of Selenium Deficiency in China.- Ultratrace Elements: An Update.- The Influence of the Ultra TraceElement Deficiency (Mo, Ni, As, Cd, V) on Growth, Reproduction Performance and Life Expectancy.- Hormones and Vitamins.- Manganese as a Potential Modulator of Second Messenger Pathways.- Metabolism of Trace Metals in Ascorbic Acid Deficiency: With Special Regard to Zinc Metabolism.- Metal-Binding Proteins and Metalloenzymes.- Metallothionein: Biochemistry and Spatial Structure.- Metallothionein and Zinc Deficiency.- Synthesis and Properties of a Selenium Analogue of Metallothionein.- Transport of Copper.- New Analytical Techniques for Trace Elements.- ICP-MS-Application to Biological Samples.- Role of Reference Materials for Validation of Analytical Data in Trace Element Analysis of Biological Materials.- A Guideline for Application of Neutron Activation Analysis to Biological and Medical Samples.- Summary of New Analytical Techniques and General Discussion.- Environment and Trace Elements.- Aluminum Toxicity in Humans.- Methylmercury Toxicity.- Advances in the Toxicology of Inorganic Mercury.- Current Topics on the Toxicology of Inorganic Lead.- Cadmium Accumulation in Human Tissues: Relationship to Development of Toxic Effects.- Factors Aggravating Cadmium Health Effects in Old Animals.- Author Index.- Key Word Index.