Farnesyltransferase Inhibitors in Cancer Therapy
Humana Press Inc. (Verlag)
978-1-4684-9606-2 (ISBN)
1 Signal Transduction Pathways: A Goldmine for Therapeutic Targets.- 2 The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I.- 3 Structures of Protein Farnesyltransferase.- 4 Peptidomimetic-Based Inhibitors of Farnesyltransferase.- 5 Antitumor Efficacy of a Farnesyltransferase Inhibitor in Transgenic Mice.- 6 Development of Farnesyltransferase Inhibitors as Potential Antitumor Agents.- 7 Tricyclic Farnesyl Protein Transferase Inhibitors: Antitumor Activity and Effects on Protein Prenylation.- 8 Histidylbenzylglycinamides: A Novel Class of Farnesyl DiphosphateCompetitive Peptidic Farnesyltransferase Inhibitors.- 9 From Random Screening of Chemical Libraries to the Optimization of FPP-Competitive Inhibitors of Farnesyltransferase.- 10 Genetic Analysis of FTase and GGTase I and Natural Product Farnesyltransferase Inhibitors.- 11 Effects of Farnesyltransferase Inhibitors on Cytoskeleton, Cell Transformation, and Tumorigenesis: The FTI-Rho Hypothesis.- 12 Prenyltransferase Inhibitors as Radiosensitizers.- 13 Farnesyltransferase and Geranylgeranyltransferase I Inhibitors as Novel Agents for Cancer and Cardiovascular Diseases.- 14 Protein Prenylation in Trypanosomatids: A New Piggy-Back Medicinal Chemistry Target for the Development of Agents Against Tropical Diseases.- 15 Early Clinical Experience with Farnesyl Protein Transferase Inhibitors: From the Bench to the Bedside.- 16 Phase I Trial of Oral R115777 in Patients with Refractory Solid Tumors: Preliminary Results.- 17 Farnesyltransferase and Geranylgeranyltransferase Inhibitors: The Saga Continues.
Reihe/Serie | Cancer Drug Discovery and Development |
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Zusatzinfo | XII, 280 p. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
Medizin / Pharmazie ► Pflege | |
Medizin / Pharmazie ► Pharmazie | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Chemie ► Technische Chemie | |
Technik | |
ISBN-10 | 1-4684-9606-9 / 1468496069 |
ISBN-13 | 978-1-4684-9606-2 / 9781468496062 |
Zustand | Neuware |
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