Nuclear Transport

The Structure and Composition of the Yeast NPC.- 1 Introduction.- 2 Overview of the Yeast NPC Structure.- 3 Yeast Nucleoporins: What's NUP, What's Not.- 4 The Yeast NPC as a Dynamic Structure.- 5 Putting It All Together: The Internal Organization of the Yeast NPC.- 6 Functional Environment of the Yeast NPC: The Interactions with Its Neighbors.- 7 Mechanism of Nucleocytoplasmic Transport.- References.- The Vertebrate Nuclear Pore Complex: From Structure to Function.- 1 Introduction.- 2 Toward the Three-Dimensional Architecture of the Nuclear Pore Complex.- 3 Molecular Constituents of the Nuclear Pore Complex: The Nucleoporins.- 4 What Is the Functional Significance of the Multiple Locations of Nucleoporins?.- 5 From Nuclear Pore Complex Structure to Nucleocytoplasmic Transport.- 6 Concluding Remarks.- References.- How Ran Is Regulated.- 1 Ran Belongs to the Superfamily of Ras-Related Proteins.- 2 Ran.- 3 Stimulation of Guanine Nucleotide Exchange by RanGEF.- 4 Induction of the Ran GTPase by RanGAP.- 5 Role of Ran in Protein Import.- 6 Effects of Importin-?-Related Proteins on the Activities of Ran.- 7 Recycling of Exported Import Factors by RanBP1/RanBP2.- 8 Export of Macromolecules from the Nucleus.- 9 Role of RanBP3 in Exportin-l-Mediated Export.- 10 Import of Ran into the Nucleus.- 11 Mogl Induces Release of GTP from Ran.- 12 RanGTP in Mitosis.- References.- Exportin-Mediated Nuclear Export of Proteins and Ribonucleoproteins.- 1 Introduction.- 2 Ran Is King.- 3 Exportins.- 4 CRM1/Exportin-1.- 5 Exportin-Mediated Export of Ribonucleoproteins.- 6 Exportin-4.- 7 Msn5/Exportin-5.- 8 Interaction of Exportins with the Nuclear Pore Complex.- 9 Perspectives.- References.- Structures of Importins.- 1 Introduction.- 2 NLS Recognition: Association with a.- 3 Cargo Bindingto the Receptor: Importin-?-Binding Association with ?.- 4 Cargo Release: RanGTP Binding to ? and ?2.- 5 Nuclear Pore Complex Docking.- 6 From Static Snapshots to a Dynamic Picture.- Addendum.- References.- Nuclear Export of tRNA.- 1 Introduction.- 2 tRNA Processing: Preparation to Exit the Nucleus?.- 3 A Distinct Pathway for the Nuclear Export of Mature tRNA.- 4 Identification of Los 1p/Xpo-t as a Nuclear Export Receptor for tRNA.- 5 Structural Requirements for the Xpo-t/tRNA Interaction: A Proofreading Mechanism?.- 6 An Alternative Nuclear tRNA Export Pathway and the Role of Aminoacylation.- 7 Nuclear tRNA Export as a Regulatory Mechanism?.- 8 Concluding Remarks.- References.- Nuclear Export of Messenger RNA.- 1 Introduction.- 2 RAE1/Gle2p and TAP/Mex67p May Function as Nuclear Export Receptors for mRNA.- 3 Role of hnRNP-Like Proteins in mRNA Export.- 4 Export of Spliced and Unspliced mRNAs.- 5 Disassembly of Export Complexes and Recycling of Export Factors: The Role of Dbp5.- 6 Perspectives.- References.- Using Retroviruses To Study the Nuclear Export of mRNA.- 1 Nuclear mRNA Export and the Retroviral Life Cycle.- 2 Crml-Dependent Retroviral mRNA Export.- 3 Tap-Dependent Retroviral mRNA Export.- 4 Other Retroviruses, Other Pathways?.- References.- Regulated Nuclear Transport.- 1 Introduction.- 2 Protein Kinases.- 3 Transcription Factors.- 4 Stress Regulation of Nuclear mRNA Export.- 5 Some General Conclusions.- References.