Microbial DNA and Host Immunity

I: Introduction.- 1 Immunostimulatory DNA: An Overview.- 2 Historical Perspectives.- II: Receptors and Signaling.- 3 Signal Transduction Pathways Activated By CpG-DNA.- 4 A Novel Toll-Like Receptor that Recognizes Bacterial DNA.- 5 Activation of Innate Immunity by Microbial Nucleic Acids.- 6 Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG.- III: Cell Activation.- 7 Activation of NK Cell By Immunostimulatory Oligo-DNA in Mouse and Human.- 8 Regulation of Antigen Presenting Cell Function by CpG DNA.- 9 Activation of B Cells by CpG Motifs in Bacterial DNA.- 10 IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells.- 11 Cross-Priming of CD8+ T Cells by Immunostimulatory Sequence DNA.- IV: Vaccination Strategies.- 12 The Th1 Adjuvant Effect of Immunostimulatory (ISS) DNA Sequences.- 13 Immunostimulatory DNA Prepriming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses.- 14 Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen.- 15 Immunostimulatory DNA Sequence-Based Mucosal Vaccines.- 16 Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence by Liposomal Delivery.- 17 Immunostimulatory Sequences in Plasmid Vectors.- V: Applications—Infectious Disease.- 18 Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B.- 19 Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine?.- 20 Immunoprotective Activity of CpG Oligonucleotides.- 21 Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection.- VI: Applications—Allergy.- 22 DNA-Based Immunotherapeutics For Allergic Disease.- 23 Immunostimulatory DNA for Allergic Asthma.- 24 CpG Oligodeoxynucleotides in Asthma.- 25 Modulation of Allergic Conjunctivitis by Immunostimulatory DNA SequenceOligonucleotides.- VII: Applications—Cancer.- 26 CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma.- VIII: Inflammation and Autoimmunity.- 27 The Antigenicity of Bacterial DNA.- 28 Inflammatogenic Properties of Immunostimulatory DNA Sequences.- 29 The Role of Immunostimulatory DNA Sequences in Arthritis.- 30 Effects of Immunostimulatory DNA Oligonucleotides on Experimental Colitis.- IX: Safety Considerations.- 31 CpG ODN—Safety Considerations.