Handbook of Experimental Pharmacology / Fibrinolytics and Antifibrinolytics

This book covers basic aspects of the molecular biology, biochemistry and pharmacology of the plasminogen-plasmin (fibrinolytic) system. Individual chapters, written by well-known experts in the field, are devoted to plasminogen and its activation, the tissue-type plasminogen activator (tPA), the urinary-type-plasminogen activator (uPA), inhibitors of the fibrinolytic system, and the assembly of fibrinolytic constituents on cell surfaces. The major part of the book deals with the therapeutic use of thrombolytic agents in myocardial infarction, deep venous thrombosis, pulmonary embolism, peripheral arterial occlusions and stroke. The newest thrombolytic agents are discussed in depth. Results of major clinical trials up to the end of 1999 are critically evaluated. The volume is a modern up-to-date presentation of the entire field of the treatment of arterial and venous thromboses with thrombolytic agents. TOC:From the contents: Molecular Biology, Biochemistry, Physiology, and Pharmacology of the Plasminogen-Plasmin Enzyme System.- II: Clinical Use of Thrombolytic Agents: In Acute Myocardial Infarction; Thrombolytic Treatment of Other Clinical Thromboembolic Conditions; Thrombolytic Agents in Development, Biochemistry, Pharmacology, Efficacy in Animal Experiments and First Clinical Trials.The complete table of contents can be found on the Internet: http://www.springer.de