DNA Topoisomearases: Biochemistry and Molecular Biology

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children. Joseph T. Coyle, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA Leroy F. Liu serves as the Chair and Professor in the Department of Pharmacology at the Robert Wood Johnson Medical School in Piscataway, New Jersey. Dr. Liu earned his B.S. in Chemistry at the National Taiwan University in 1971. He attended the University of California, Berkeley, and received his doctorate in Biophysical Chemistry in 1977. Liu has also held various teaching positions, including Visiting Professor at Academic Sinica in Taiwan and both Assistant and Associate Professor at the Johns Hopkins University School of Medicine.A Searle Scholar (1981-1984), Liu was awarded the American Chemical Society Faculty Research Award (1985-1990) and the George H. Hitchings Award for Innovative Drug Design in 1989. Dr. Liu's research interests include Topoisomerases in DNA structure and function, DNA damage and repair, and cancer biology and pharmacology. Along with this contribution to Advances in Pharmacology, Liu has written more than 100 scientific articles.

J.C. Wang, DNA Topoisomerases as Targets of Therapeutics: An Overview.Y.-C. Tse-Dinh, Biochemistry of Bacterial Type I DNA Topoisomerases.R. Menzel and M. Gellert, The Biochemistry and Biology of DNA Gyrase.J.J. Champoux, Mechanism of Catalysis by Eukaryotic DNA Topoisomerase I.A.H. Andersen, J.Q. Svejstrup, and O. Westergaard, The DNA Binding, Cleavage, and Religation Reactions of Eukaryotic Topoisomerases I and II.J.L. Nitiss, Roles of DNA Topoisomerases in Chromosomal Replication and Segregation.M. Drolet, H.-Y. Wu., and L.F. Liu, Roles of DNA Topoisomerases in Transcription.H. Ikeda, DNA Topoisomerase-Mediated Illegitimate Recombination.J. Hwang and C.-L. Hwong,Cellular Regulation of Mammalian DNA Topoisomerases.T.-s. Hsieh, M.P. Lee, and S.D. Brown, Structure of Eurkaryotic Type I DNA Topoisomerase.W.M. Huang, Type II DNA Topoisomerase Genes.H.C. Neu, Major Advances in Antibacterial Quinolone Therapy.K. Drlica and B. Kreiswirth, 4-Quinolones and the Physiology of DNA Gyrase.L.L. Shen, Molecular Mechanisms of DNA Gyrase Inhibition by Quinolone Antibacterials.References.Subject Index.