Advances in Enzyme Regulation

Part 1 Regulation through signal transduction: regulation of signal transduction, G. Weber et al; nuclear inositol lipid cycle and differentiation, L. Cocco et al. Part 2 Control through oncogenes: regulation of c-myb expression in ML-1 human myeloblastic leukemia cells by C-ets-1 protein, A. Bloch et al; isolation and biological activities of signal transduction inhibitors from microorganisms and plants, K. Umezawa. Part 3 Regulation of enzymes of DNA biosynthesis: structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo, J.G. Cory et al; human thymidine kinase 1 - regulation in normal and malignant cells, B. Munch-Petersen. Part 4 Tumour metabolism and chemotherapy: glucuronidation by human colorectal adenocarcinoma cells as a mechanism of resistance to mycophenolic acid, T.J. Franklin et al; tumor metabolism - the lessons of magnetic resonance spectroscopy, M. Stubbs et al; preferential kill of hypoxic EMT6 mammary tumor cells by the bioreductive alkylating agent porfiromycin, A.C. Sartorelli et al. Part 5 Hormonal and dietary regulation: hormonal control of hepatic glutaminase, J.T. Brosnan et al; a new family of protein kinases - the mitochondrial protein kinases, R.A. Harris et al. Part 6 Regulation of lipolysis: co-ordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo - implications for the control of fat storage and fat mobilization, K.N. Frayn et al; intracellular triacylglycerol lipase - its role in the assembly of hepatic very-low-density lipoprotein (VLDL), G.F. Gibbons and D. Wiggins. Part 7 Regulation by phosphorylation and feedback: microfilament dynamics - regulation of actin polymerization by actin-fragmin kinase and phosphatases, E. Waelkens et al; mammalian phosphoribosylpyrophosphate synthetase, M. Tatibana et al. Part 8 Control by methylation and through matrix enzymes: thiopurine induced disturbance of DNA methylation in human malignant cells, R. De Abreu et al; topoisomerase II isozymes involved in anticancer drug action and resistance, D.J. Fernandes et al. Part 9 Metalloproteinase and secretory vesicles: sorting and budding of constitutive secretory vesicles in hepatocytes and hepatoma cells, A. Barthel et al; matrix metalloproteinase inhibitors - a novel class of anticancer agents, P.D. Brown. Part 10 Special symposium lecture: compartmentalization of cyclic AMP phosphodiesterases, signalling "crosstalk", desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP, M.D. Houslay. (Part Contents).