The Adenoviruses

1 An Overview.- 2 The Architecture of Adenoviruses.- I. Introduction.- II. Chemical and Physical Properties.- III. Virus Capsid: Composition and Organization.- IV. Virus Core.- References.- 3 The Structure of the Genome.- I. Introduction.- II. Grouping of Adenoviruses Based on DNA Homology.- III. Physicochemical Properties of Adenovirus DNA.- IV. Coordinate System.- V. Inverted Terminal Repetition.- VI. Terminal Protein.- VII. Organization of the Adenovirus Genome.- VIII. Comparison of Genomes and Concluding Remarks.- References.- 4 The Genetic System.- I. Introduction.- II. Production of Viral Mutants.- III. Adenovirus Mutants.- IV. Mapping Methods.- V. Genetic Interactions.- References.- 5 Adenovirus Transcription.- I. Introduction.- II. Nine Transcription Units.- III. Temporal Nature of Transcription from Adenovirus Promoters.- IV. Viral Chromatin Structure.- V. Sequence of Promoter Sites.- VI. E1a Transcription Unit.- VII. E1b Transcription Unit.- VIII. E2(75) Transcription Unit.- IX. Late Transcription Unit.- X. Regulation by Ela Protein.- XL Regulation by the 72K DNA-Binding Protein of E2.- XII. Effect of Inhibition of Protein Synthesis on Adenovirus Transcription.- XIII. Virus-Associated RNAI and RNAII.- XIV. Summary.- References.- 6 Structural and Nonstructural Adenovirus Proteins.- I. General Considerations.- II. Major Capsid Proteins.- III. Minor Polypeptides in the Adenovirus Capsid.- IV. Physiological Effects of the Structural Proteins.- V. Adenovirus Proteins Synthesized at Intermediate Times after Infection.- VI. Late Nonstructural Proteins.- VII. Structure and Function of Adenovirus Proteins Synthesized Early after Infection.- VIII. Prospectives for Future Studies of Adenovirus Proteins.- References.- 7 Adenovirus DNA Replication.- I. Introduction.- II. Structure of the Termini of Adenovirus Genomes.- III. Adenovirus DNA Replication in Vivo.- IV. Adenovirus DNA Replication in Vitro.- V. Replication Proteins.- VI. Initiation of Adenovirus DNA Replication.- References.- 8 Adenovirus Assembly.- I. Introduction.- II. Protein Neighbors in the Virion.- III. Assembly of Capsomers.- IV. Formation of Empty Capsids.- V. Insertion of Viral DNA.- VI. Proteolytic Cleavage during Maturation.- VII. Arrest of the Assembly Pathway.- VIII. Intermediate Particles in Assembly.- IX. Conclusion.- References.- 9 Transformation by and Oncogenicity of Human Adenoviruses.- I. Introduction.- II. Structure of Integrated Adenovirus DNA Sequences in Virus-Induced Tumors and in Transformed Cells..- III. Transformation by Adenovirus DNA.- IV. Transformation-Defective Mutants..- V. Tumor Antigens and Their Role in Transformation.- VI. Factors That Affect the Tumorigenicity of Adenovirus-Transformed Cells.- VII. Role of Adenoviruses in Naturally Occurring Cancers.- References.- 10Adenovirus-Simian Virus 40 Interactions.- I. Introduction.- II. Adenovirus-Simian Virus 40 Hybrids.- III. Human Adenovirus Growth in Monkey Cells.- IV. Complementation between Simian Virus 40 and Adenovirus Mutants.- V. Adenovirus Inhibition of Simian Virus 40 Growth.- VI. Summary.- References.- 11 Adenovirus Infections in Humans.- I. Introduction.- II. Adenoviruses Recovered from Humans.- III. Classification of Human Adenoviruses.- IV. Epidemiology and Transmission.- V. Pathology.- VI. Pathophysiology and Immune Responses.- VII. Infectious Syndromes Associated with Adenoviruses.- VIII. Diagnosis.- IX. Treatment.- X. Prevention.- XI. Adenovims-Simian Virus 40 Hybrids.- XII. Adeno-Associated Viruses.- XIII. Latency.- XIV. Further Research.- References.- 12 Adenoviruses of Animals.- I. Introduction.- II. Nomenclature and Abbreviations.- III. Structure and Components of the Viral Capsid.- IV. Viral DNA.- V. Viral Antigens and Hemagglutinins.- VI. Classification of Animal Adenoviruses (Family Adenoviridae).- VII. Natural and Experimental Infection of Animals.- VIII. Oncogenicity.- IX. Concluding Remarks.- References.- 13 Adeno-Associated Virus.- I. Introduction.- II. Virion.- III. Biology of Adeno-Associated Virus.- IV. Macromolecular Structure and Synthesis.- V. Latent Infections.- VI. Inhibition of Adenovirus.- VII. Conclusion.- References.