Blood Cell Biochemistry Volume 3

1 Biochemical, Immunological, and Molecular Markers of Hemopoietic Precursor Cells.- 1. Introduction.- 2. Biochemical Markers.- 3. Immunological Markers.- 4. Molecular Markers.- 5. Analysis of Human Hemopoietic Ontogenesis by Immunological and Molecular Markers.- 6. New Opportunities for Immunological and Molecular Markers: Minimal Residual Disease Detection and Therapeutical Approaches.- 7. References.- 2 Cell Surface Markers in Leukemia and Lymphoma.- 1. Introduction.- 2. B Cells.- 3. T Cells.- 4. Myeloid Cells.- 5. Summary.- 6. References.- 3 Cytoskeletal Organization of Normal and Leukemic Lymphocytes and Lymphoblasts.- 1. Introduction.- 2. Microfilaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 3. Intermediate-Size Filaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 4. Microtubules in Lymphoid Cells.- 5. Organization of Spectrin in Lymphocytes.- 6. Conclusions.- 7. References.- 4 Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation.- 1. Introduction.- 2. B-Cell Antigen Receptor-Mediated Signaling.- 3. Molecular Bases of T-Cell-Mediated B-Cell Signaling.- 4. Biological Evidence for Ia-Mediated Signal Transduction.- 5. Biochemical Evidence for Ia-Mediated Signal Transduction.- 6. Conclusions.- 7. References.- 5 IgE Receptors on Lymphocytes and IgE-Binding Factors.- 1. Introduction.- 2. Historical Overview.- 3. Fc?RII on Lymphocytes.- 4. IgE-Binding Factors.- 5. Glycosylation-Regulating Factors: GEF and GIF.- 6. Interleukin 4 and Gamma Interferon.- 7. CD23 Antigen.- 8. Conclusion.- 9. References.- 6 Lymphocyte-Mediated Cytolysis: Role of Granule Mediators.- 1. Role of Granules and Perform in Lymphocyte-Mediated Killing.- 2. Other Candidate Mechanisms of Lymphocyte-Mediated Killing.- 3. Resistance of Lymphocytes to Self-MediatedKilling.- 4. Conclusion.- 5. References.- 7 CR1—Cytoskeleton Interactions in Neutrophils.- 1. Introduction.- 2. Detergent Extraction of Cells.- 3. Receptor—Cytoskeleton Interactions.- 4. The C3b Receptor (CR1).- 5. References.- 8 The Flow of Granular Organelles in Leukocyte Differentiation.- 1. Introduction.- 2. Biogenesis of Membrane-Bound Organelles.- 3. Leukocyte Granules are Major Determinants of Function.- 4. Granules Interact with the Plasma Membrane.- 5. Pathology of Myeloid Granules and Plasma Membranes.- 6. Conclusion.- 7. References.- 9 The Elusive Oxidase: The Respiratory Burst Oxidase of Human Phagocytes.- 1. Introduction.- 2. The Respiratory Burst.- 3. The Activated NADPH Oxidase.- 4. Identification of Components of the Oxidase.- 5. Postulated Components of the NADPH Oxidase.- 6. Summary.- 7. References.- 10 Myeloperoxidase: Localization, Structure, and Function.- 1. Introduction.- 2. Background.- 3. Structure.- 4. Synthesis.- 5. Molecular Biology: The Myeloperoxidase Gene.- 6. Function.- 7. References.- 11 Mechanisms of Oxidase Activation in Neutrophils: Importance of Intracellular Calcium and Cytoskeletal Interactions.- 1. Importance of the Neutrophil Oxidase in Physiology and Pathology.- 2. The Neutrophil Oxidase.- 3. Stimulus—Oxidase Activation Coupling.- 4. Cytoskeletal Components and Neutrophil Activity.- 5. Actin Polymerization and Oxidase Activation.- 6. Conclusion.- 7. References.- 12 Neutrophil and Eosinophil Granules as Stores of “Defense” Proteins.- 1. Introduction.- 2. The Vacuolar Apparatus of Granulocytes.- 3. Defense Polypeptides of Granulocytes.- 4. Conclusions.- 5. References.- 13 Membrane Glycoproteins of Mast Cells and Basophils.- 1. Introduction.- 2. Receptors for Complement Anaphylatoxins on Mast Cells and Basophils.- 3.Immunoglobulin Receptors on Mast Cells and Basophils.- 4 Immunoglobulin E on Mast Cells and Basophils.- 5. Hemopoietic Lineage-Associated Membrane Glycoproteins of Mast Cells and Basophils.- 6. References.