Molecular and Cellular Biology of Neuroprotection in the CNS

I. Neuronal Cell Death Overview of Basic Mechanisms.- 1. Excitatory Amino Acid Neurotoxicity.- 2. Neuronal Survival and Cell Death Signaling Pathways.- 3. Detrimental and Beneficial Effects of Injury-Induced Inflammation and Cytokine Expression in the Nervous System.- 4. Cellular and Molecular Determinants of Glial Scar Formation.- II. Ion Channels, Receptors and Signaling Pathways.- 5. Na+ Channels and Ca 2+ Channels of the Cell Membrane As Targets of Neuroprotective Substances.- 6. Intracellular Ca2+ Handling.- 7. Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands.- 8. A Role for Glutamate Transporters in Neurodegenerative Diseases.- 9. Purines and Neuroprotection.- 10. Heat Shock Proteins and Neuroprotection.- III. Neurotrophic Factors as Neuroprotective Agents.- 11. Neurotrophins.- 12. Fibroblast Growth Factors and Neuroprotection.- 13. TGF-ßS and Their Roles in the Regulation of Neuron Survival.- 14. Vascular Endothelial Growth Factor.- IV. Advances in Drug Delivery to CNS Neurons.- 15. Blood-Brain Barrier Drug Targeting Enables Neuroprotection in Brain Ischemia Following Delayed Intravenous Administration of Neurotrophins.- 16. Invasive Drug Delivery.- V. Neuroprotective Strategies in Animal and in Vitro Models of Neuronal Damage.- 17. Ischemia and Stroke.- 18. Neuroprotective Strategies in Alzheimer’s Disease.