Antihypertensive Therapy

Opening remarks.- Experimental basis of antihypertensive treatment.- Pharmacology of the sympathetic nervous system.- Mode of action of antihypertensive drugs.- Pharmacology of diuretics.- Functional, biochemical, and morphological changes produced by hypotensive drugs.- Influence of sleep on circulation in normal and hypertensive animals.- Hypertension and vascular disease.- Experimental atherosclerosis and hypertension.- The vascular crisis in hypertension.- Vascular disease and hypertension.- Retinal vascular alterations in hypertension.- The heart and hypertension.- General principles in antihypertensive treatment.- Assessment of antihypertensive therapy.- Selection of patients for antihypertensive therapy.- Methodology of blood-pressure recording.- Spontaneous blood-pressure variations in hypertension; the effect of antihypertensive therapy and correlations with the incidence of complications.- Effect of a simple therapeutic regimen on blood pressure and its variability in mild hypertension.- Clinical pharmacology and short-term treatment.- Haemodynamic analysis of some principles applied in the treatment of arterial hypertension.- Some biochemical aspects of treatment and diagnosis of hypertension.- Advantages and disadvantages of combined drug treatment.- Management of hypertensive crisis.- Hypertension in pregnancy and its treatment.- Long-term treatment.- Organization of a long-term multiclinic therapeutic trial in hypertension.- Prognosis in retinal Grade I and II patients.- Analysis of mortality and survival in actively treated hypertensive disease.- The present status of symptomatic surgical treatment for arterial hypertension.- Potassium loss and potassium replacement during long-term diuretic treatment in hypertension.- Disturbances in carbohydrate and uric-acid metabolism during diuretic treatment.- Comparison of long-term effects of saluretics and of anabolic steroids on renal functions.- Diagnosis and treatment of renovascular and other forms of renal hypertension.- Diagnosis of renal artery stenosis.- The diagnostic value of renal biopsy in renovascular and other forms of renal hypertension.- Diagnostic value of selective renal arteriography in hypertension.- Diagnostic significance of humoral factors in renovascular hypertension.- Conservative treatment of renovascular hypertension.- Some observations on the filtration fraction, on the transport of sodium and water in the ischemic kidney, and on the prognostic importance of R.P.F. to the contralateral kidney in renovascular hypertension.- Hypertension and nephritis.- Drug treatment of hypertension.- Closing remarks.- List of authors.