Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control -

Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control

Insights for Drug Discovery

Tucker Collins (Herausgeber)

Buch | Softcover
327 Seiten
2012 | Softcover reprint of the original 1st ed. 2001
Springer-Verlag New York Inc.
978-1-4613-5617-2 (ISBN)
160,49 inkl. MwSt
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers.
This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment.
This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.

1. The Selectins in Leukocyte Recruitment.- 2. Transcriptional Regulation of the E-Selectin Gene.- 3. The Immunoglobulin Superfamily in Leukocyte Recruitment.- 4. Regulation of Intercellular Adhesion Molecule (ICAM) Gene Expression.- 5. Transcriptional Regulation of VCAM-1.- 6. Activation of Nuclear Factor-KB.- 7. The Basal Transcriptional Apparatus.- 8. Therapeutic Regulation of Leukocyte Adhesion Molecule Expression.- 9. The NF-kB System and Drug Discovery.

Zusatzinfo XIII, 327 p.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizinische Fachgebiete Innere Medizin Hämatologie
Medizinische Fachgebiete Innere Medizin Pneumologie
Medizin / Pharmazie Studium 1. Studienabschnitt (Vorklinik)
Studium 2. Studienabschnitt (Klinik) Pathologie
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Veterinärmedizin
ISBN-10 1-4613-5617-2 / 1461356172
ISBN-13 978-1-4613-5617-2 / 9781461356172
Zustand Neuware
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