Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control
Springer-Verlag New York Inc.
978-1-4613-5617-2 (ISBN)
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This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment.
This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.
Preface: Transcriptional Control of Cell Adhesion Molecules; T. Collins, M. Gerritsen. 1. The Selectins in Leukocyte Recruitment; R. McEver. 2. Transcriptional Regulation of the E-Selectin Gene; T. Collins, K.-A. Sheppard, S. Simeonidis, D. Rose. 3. The Immunoglobulin Superfamily in Leukocyte Recruitment; U. von Andrian. 4. Regulation of Intercellular Adhesion Molecule-1 Gene Expression; T. Parks, M. Gerritsen. 5. Transcriptional Regulation of VCAM-1; A. Neish, S. Aggarwal, T. Collins. 6. Activation of Nuclear Factor-kappaB; F. Lee, R. Peters, J. Chen, T. Maniatis. 7. The Basal Transcriptional Apparatus; S. Anderson, J. Parvin. 8. Therapeutic Regulation of Leukocyte Adhesion Molecule Expression; M. Gerritsen. 9. The NF-kappaB System and Drug Discovery; A. Manning. Index.
Zusatzinfo | XIII, 327 p. |
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Verlagsort | New York, NY |
Sprache | englisch |
Maße | 155 x 235 mm |
Gewicht | 528 g |
Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Hämatologie |
Medizinische Fachgebiete ► Innere Medizin ► Pneumologie | |
Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik) | |
Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
Veterinärmedizin | |
ISBN-10 | 1-4613-5617-2 / 1461356172 |
ISBN-13 | 978-1-4613-5617-2 / 9781461356172 |
Zustand | Neuware |
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