Nanoparticulate Drug Delivery Systems (eBook)

YOON YEO, PhD, is Assistant Professor of Industrial and Physical Pharmacy at the College of Pharmacy at Purdue University. She also holds a joint appointment as Assistant Professor at Purdue's Weldon School of Biomedical Engineering. Her research focuses on nanoparticle surface engineering for drug delivery to solid tumors, inhalable drug/gene delivery for cystic fibrosis therapy, and functional biomaterials based on carbohydrates. Dr. Yeo is the recipient of the NSF CAREER Award as well as New Investigator awards from both the American Association of Pharmaceutical Scientists and the American Association of Colleges of Pharmacy.

Preface vii

Contributors ix

1 Tumor-Targeted Nanoparticles: State-of-the-Art and Remaining
Challenges 1

Gaurav Bajaj and Yoon Yeo

2 Applications of Ligand-Engineered Nanomedicines 21

Gayong Shim, Joo Yeon Park, Lee Dong Roh, Yu-Kyoung Oh, and
Sangbin Lee

3 Lipid Nanoparticles for the Delivery of Nucleic Acids 51

Yuhua Wang and Leaf Huang

4 Photosensitive Liposomes as Potential Targeted Therapeutic
Agents 81

David H. Thompson, Pochi Shum, Oleg V. Gerasimov, and Marquita
Qualls

5 Multifunctional Dendritic Nanocarriers: The Architecture and
Applications in Targeted Drug Delivery 101

Ryan M. Pearson, Jin Woo Bae, and Seungpyo Hong

6 Chitosan-Based Nanoparticles for Biomedical Applications
129

Heebeom Koo, Kuiwon Choi, Ick Chan Kwon, and Kwangmeyung
Kim

7 Polymer-Drug Nanoconjugates 151

Rong Tong, Li Tang, Nathan P. Gabrielson, Qian Yin, and Jianjun
Cheng

8 Nanocrystals Production, Characterization, and Application for
Cancer Therapy 183

Christin P. Hollis and Tonglei Li

9 Clearance of Nanoparticles During Circulation 209

Seung-Young Lee and Ji-Xin Cheng

10 Drug Delivery Strategies for Combating Multiple Drug
Resistance 241

Joseph W. Nichols and You Han Bae

11 Intracellular Trafficking of Nanoparticles: Implications for
Therapeutic Efficacy of the Encapsulated Drug 261

Lin Niu and Jayanth Panyam

12 Toxicological Assessment of Nanomedicine 281

Hayley Nehoff, Sebastien Taurin, and Khaled Greish

Index 307