Adenosine and Adenine Nucleotides As Regulators of Cellular Function

John W. Phillis

INTRODUCTION. Historical Perspectives-Adenosine (D.J. Cushing and S.J. Mustafa). Historical Perspectives-ATP (D. Satchell). PURINE RECEPTORS, METABOLISM, RELEASE, AND TRANSPORT. Adenosine Receptors: Ligand-Binding Studies (U. Schwabe). Adenosine Receptors, Adenylate Cyclase; Relationships to Pharmacological Actions of Adenosine (R.D. Green). Formation and Metabolism of Adenosine and Adenine Nucleotides in Cardiac Tissue (J. Schrader). Adenosine Deaminase Regulation of Purine Actions (J.D. Geiger, R.A. Padua, and J.I. Nagy). Nucleoside Transport in Cells: Kinetics and Inhibitor Effects (L. Hertz). Adenosine and Adenine Nucleotides in Tissues and Perfusates (T.D. White and K. Hoehn). FUNCTIONS OF PURINES AT THE CELLULAR LEVEL. Adenosine, Adenine Nucleotides and Platelet Function (N.J. Cusack and S.M.O. Hourani). Purines and Inflammation: Neutrophils Possess P1 and P2 Purine Receptors (B.N. Cronstein). Adenosine and Immune System Function (T.S. Priebe and J.A. Nelson). Purinergic Regulation of Transmitter Release (J.A. Ribeiro). ADENOSINE AND BLOOD FLOW IN VASCULAR BEDS. Effect of Adenosine on the Coronary Circulation (M.G. Collis). Purinergic Control of Skeletal Muscle Blood Flow (M.W. Gorman, S.S. Kelley, L. Kaiser, and H.V. Sparks). Adenosine and the Regulation of Cerebral Blood Flow (D.G.L. Van Wylen, V.M. Sciotti, and H.R. Winn). Adenosine and Blood Flow Through the Gastrointestinal Tract (K.G. Proctor and B. Langkamp-Henken). Adenosine-Mediated Regulation of Hepatic Blood Flow (W.E. Lautt). Effects of Adenosine and Adenine Nucleotides on the Pulmonary Circulation (A. Hyman, B. Cai, C. Feng, Q. Hao, and H. Lippton). The Role of Adenosine in Angiogenesis (C.J. Meininger and H.J. Granger). ACTIONS OF ADENOSINE ON BODY SYSTEMS. Influence of Adenosine on Cardiac Activity (M.G. Collis). Adenosine Receptor Activation and Renal Function (W.G. Spielman). Purinergic Regulation of Gastrointestinal Motility and Secretion (M.A. Cook). Effects of Adenosine Infusion on the Cons