Cancer Epigenetics (eBook)

Antonio Giordano, M.D., Ph. D., is professor of biology and medical research at Temple University College of Science and Technology in Philadelphia, Pennsylvania. In 1993 he co-founded the Sbarro Institute for Cancer Research and Molecular Medicine. He has been honored as Knight by the president of Italy and is recipient of the National Italian-American Political Action Committee (NIA-PAC) National Lifetime Achievement Award in Medical Research. Marcella Macaluso, Ph.D., is associate professor of biology and a researcher in the Hormone-Signaling and Cancer Program of the Sbarro Institute for Cancer Research at Temple University in Philadelphia.

Contributors.

Preface.

SECTION I: EPIGENETICS AND CELL CYCLE.

1 Epigenetic Modulation of Cell Cycle: An Overview (Micaela
Montanari, Antonio Giordano, Marcella Cintorino, and Marcella
Macaluso).

SECTION II: EPIGENETICS AND CELL DEVELOPMENT, SENESCENCE AND
DIFFERENTIATION.

2 Epigenetics in Skeletal Muscle Development (Cristina
Giacinti and Antonio Giordano).

3 Epigenetic Control in Cellular Senescence (Heike Helmbold,
Wolfgang Deppert, and Wolfgang Bohn).

4 Epigenetic Modulation in Cell Development and Differentiation
(Mario Mancino, Claudia Esposito, Raffaella Pasquale, Immacolata
Vocca, and Francesca Pentimalli).

SECTION III: EPIGENETICS AND GENE TRANSCRIPTION.

5 Epigenetic Control of Gene Transcription (Christian
Bronner, Mayada Achour, Thierry Chataigneau,and Valerie B.
Schini-Kerth).

6 Epigenetics, MicroRNAs, and Cancer: An Update (Giuseppe
Russo, Andrew Puca, Francesco Masulli, Stefano Rovetta,Letizia
Cito, Debora Muresu, Flavio Rizzolio, and Antonio
Giordano).

SECTION IV: EPIGENETICS AND CANCER.

7 The Role of Epigenetic Modifications in Cancer (Michael J.
Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon,Alexander
Mazo, and Richard G. Pestell).

8 MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and
Other Diseases (Serena Buontempo, Mara Sannai, and Alfonso
Bellacosa).

9 Epigenetics in Pediatric Cancers (Roberta Ciarapica,
Lavinia Raimondi, Federica Verginelli, and Rossella Rota).

10 Epigenetic Mechanisms in Cancer Formation and Progression
(Elisabetta Fratta, Luca Sigalotti, Alessia Covre, Giulia
Parisi, Riccardo Danielli, Hugues Jean Marie Nicolay, Sandra Coral,
and Michele Maio).

SECTION V: EPIGENETICS AND ANTICANCER DRUG DEVELOPMENT AND
THERAPY.

11 Recent Advances in the Field of Stem Cell Research: Toward
the Definition of the Epigenetic and Genetic Codes of Pluripotency
(Gaetano Romano).

12 Potential of Heat Shock Protein Targeting for Human Therapy
(Laszlo Otvos, Jr).

13 Advances in Stem Cell Therapy for Cancer Research (Andrew
Puca and Antonio Giordano).

14 Epigenetic Targets and Drug Development (Paraskevi
Vogiatzi, Maria Irene Scarano, and Pier Paolo Claudio).

Index.

"In summary, this book provides a useful in-depth review
of the molecular mechanisms which underpin epigenetic processes,
their clinical linkage to cancer, particularly paediatric
indications, and the therapeutic potential of targeting epigenetic
mechanisms. It is of value to those working in, or entering, this
complex and fast-moving field and will be most accessible to those
with a biological background and interest."
(ChemMedChem, 1 July 2013)