Cancer Vaccines and Tumor Immunity (eBook)

Rimas J. Orentas, PhD, is Associate Professor in the Department of Pediatrics, Section of Hematology-Oncology, and holds joint appointments in the Departments of Medicine and Microbiology and Molecular Genetics at the Medical College of Wisconsin in Milwaukee, Wisconsin. James W. Hodge, PhD, is a Senior Scientist in the Laboratory of Tumor Immunology and Biology at the National Cancer Institute in Bethesda, Maryland. Bryon D. Johnson, PhD, is Associate Professor in the Department ofPediatrics, Section of Hematology-Oncology at the Medical College of Wisconsin in Milwaukee, Wisconsin.

Contributors.

Foreword. Cancer Vaccines and Cancer Immunotherapy. A New
Paradigm(Jeffrey Schlom).

PART I. INTRODUCTION.

Chapter 1. Cancer Vaccines. Progress and Promise (Rimas J.
Orentas, Bryon Johnson, and James Hodge).

PART II. ADJUVANT THERAPY: ENHANCING THE ENDOGENOUS IMMUNE
RESPONSE.

Chapter 2. Fully Synthetic Carbohydrate-Based Anti-Tumor
Vaccines (Rebecca M. Wilson and Samuel J. Danishefsky).

Chapter 3. Bacillus Calmette-Guerin Immunotherapy of
Genitourinary Cancer (Donald L. Lamm).

Chapter 4. Stimulation of Toll-like Receptor 9 for Enhancing
Vaccination (Daniel E. Speiser and Arthur M. Krieg).

PART III. ANTIGEN-SPECIFIC THERAPY: NOVEL PRESENTATION OF
PEPTIDE AND PROTEIN ANTIGENS.

Chapter 5. Polyepitope Vaccines (Corey Smith and Rajiv
Khanna).

Chapter 6. Antigen-Specific Cancer Immunotherapy: HPV-Associated
Cervical Cancer as a Model System (Shaw-Wei D. Tsen, Chien-Fu Hung,
and T.-C. Wu).

Chapter 7. Poxviral Vectors for Cancer Vaccines: State of the
Art (Elizabeth K. Wansley).

Chapter 8. Immunotherapeutic Strategies Against Cancer Using
Listeria Monocytogenes as a Vector for Tumor Antigens
(Nicholas C. Souders, Thorsten Verch and Yvonne Paterson).

Chapter 9. Coupling Innate and Adaptive Immunity with
Yeast-based Cancer Immunotherapy (Sibyl Munson, Joanne Parker, Tom
King, Yingnian Lu, Victoria Kelley, Zhimin Guo, Virginia Borges,
and Alex Franzusoff).

PART IV. CELL-BASED THERAPY: USING CANCER CELLS AS A MEANS TO
INDUCE SPECIFIC TUMOR IMMUNITY.

Chapter 10. Allogeneic Whole Cell Vaccines (John Copier and
Angus Dalgleish).

Chapter 11. Jump-Starting Tumor Immunity with Breast Cancer
Therapeutics (Leisha A. Emens).

Chapter 12. T-Regulatory Cell Manipulation in Tumor
Immunotherapy (Jens Rüter, Brian G. Barnett, Ilona Kryczek,
Michael J. Brumlik, Benjamin J. Daniel, George Coukos, Weiping Zou,
Tyler J. Curiel).

Chapter 13. Tumor Vaccination after Autologous HSCT: What has
been Learned from Experimental Models? (Weiqing Jing and Bryon D.
Johnson).

Chapter 14. Vaccines in the Setting of Hematopoietic Stem Cell
Transplantation (Ronald Gress and Claude Sportes).

Chapter 15. Intratumor Generation of Vigorous Antitumor Immune
Responses (Ping Yu and Yang-Xin Fu).

Chapter 16. Cancer Immunotherapy: Untapping the Potential of
Co-Stimulatory Molecules Beyond CTLA-4 (Mathew Augustine, and
Lieping Chen).

PART V. DEFINING EFFECTIVE CLINICAL RESPONSES.

Chapter 17. Advances in Immune Monitoring Strategies for Cancer
Vaccines and Immunotherapy (Seunghee Kim-Schulze, Moshe Ornstein
and Howard L. Kaufman).

Chapter 18. Immune Evaluation of Cancer Vaccines (Theresa L.
Whiteside).

Index.