Botulinum Neurotoxins (eBook)

Preface.- Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes. - Assembly and function of the Botulinum neurotoxin progenitor complex.- Uptake of botulinum neurotoxin in the intestine.- Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.- The elusive compass of clostridial neurotoxins: deciding when and where to go?.- Synchronized chaperone function of botulinum neurotoxin domains mediates light chain translocation into neurons.- Clostridial  neurotoxins light chains:devices for SNARE cleavage mediated blockade of neurotransmission.-Synaptic vesicle proteins – targets and routes for botulinum neurotoxins.- Persistence of Botulinum neurotoxin inactivation of nerve function.- Structure based drug discovery for Botulinum neurotoxins.- Complexity of botulinum neurotoxins: challenges for detection technology.- Progress in cell based assays for Botulinum neurotoxin detection.- Transforming the domain structure of botulinum neurotoxins into novel therapeutics.- Botulinum toxin: application, safety and limitations.- Subject index