Cellular Migration and Formation of Neuronal Connections

Dr. Rubenstein is a Professor in the Department of Psychiatry at the University of California, San Francisco. He also serves as a Nina Ireland Distinguished Professor in Child Psychiatry at the Nina Ireland Laboratory of Developmental Neurobiology. His research focuses on the regulatory genes that orchestrate development of the forebrain. Dr. Rubenstein's lab has demonstrated the role of specific genes in regulating neuronal specification, differentiation, migration and axon growth during embryonic development and on through adult life. His work may help to explain some of the mechanisms underlying human neurodevelopmental disorders such as autism. Dr. Rakic is currently at the Yale School of Medicine, Department of Neuroscience, where his main research interest is in the development and evolution of the human brain. After obtaining his MD from the University of Belgrade School of Medicine, his research career began in 1962 with a Fulbright Fellowship at Harvard University after which he obtained his graduate degrees in Developmental Biology and Genetics. He held a faculty position at Harvard Medical School for 8 years prior to moving to Yale University, where he founded and served as Chair of the Department of Neurobiology for 37 years, and also founder and director of the Kavli Institute for Neuroscience. In 2015, he returned to work full-time on his research projects, funded by US Public Health Services and various private foundations. He is well known for his studies of the development and evolution of the brain, in particular his discovery of basic cellular and molecular mechanisms of proliferation and migration of neurons in the cerebral cortex. He was president of the Society for Neuroscience and popularized this field with numerous lectures given in over 35 counties. In 2008, Rakic shared the inaugural Kavli Prize in Neuroscience with Thomas Jessell and Stan Grillner. He is currently the Dorys McConell Duberg Professor of Neuroscience and serves on Advisory Boards and Scientific Councils of a number of Institutions and Research Foundations.

I: Formation of Axons and DendritesChapter 1 – Development of Neuronal Polarity In Vivo - F. PolleuxChapter 2 – Role of the Cytoskeleton and Membrane Trafficking in Axon–Dendrite Morphogenesis - K.C. Flynn, M. Stiess, F. BradkeChapter 3 - Axon Growth and Branching – L. Ma, D.A. GibsonChapter 4 - Axon Guidance: Semaphorin/Neuropilin/Plexin Signaling – J. Falk, V. CastellaniChapter 5 - Roles of Eph–Ephrin Signaling in Axon Guidance –A.D. Chisholm, D.A. FeldheimChapter 6 - Axon Guidance: Slit–Robo Signaling – F. Beaubien, J.E.A. Prince, J.-F. CloutierChapter 7 - Nonconventional Axon Guidance Cues – L. Izzi, F. CharronChapter 8 - Axon Regeneration –T.L. Dickendesher, Y. Duan, R.J. GigerChapter 9 - Axon Maintenance and Degeneration – F. Wang, Z. HeChapter 10 - Dendrite Development: Invertebrates – W.B. GrueberChapter 11 - Dendritic Development: Vertebrates – C. Lohmann

II: MigrationChapter 12 - Cell Polarity and Initiation of MigrationChapter 13 - Leading Process Dynamics During Neuronal Migration – M. Valdeolmillos, F. MoyaChapter 14 – Nucleokinesis – O. Reiner, G. GerlitzChapter 15 - Migration in the Cerebellum – Y. Komuro, T. Kumada, N. Ohno, K.D. Foote, H. KomuroChapter 16 - Radial Migration in the Developing Cerebral Cortex – S.C. Noctor, C.L. Cunningham, A.R. KriegsteinChapter 17 - Radial Migration of Neurons in the Cerebral Cortex – A. Stanco, E.S. AntonChapter 18 - Migration in the Hippocampus – G. Li, S.J. PleasureChapter 19 - Hindbrain Tangential Migration – C. Sotelo, A. ChedotalChapter 20 - Tangential Migration: The Forebrain – T.J. Petros, S.A. AndersonChapter 21 - Transcriptional Regulation of Tangential Neuronal Migration in the Vertebrate Hindbrain – T. Di Meglio, F.M. RijliChapter 22 - Postnatal Neurogenesis of the Forebrain - R. Belvindrah, P.-M. LledoChapter 23 - Migration of Myelin-Forming Cells in the CNS – F. de Castro, B. ZalcChapter 24 - Neuronal Migration and Brain Patterning – A. Griveau, U. Borello, A. PieraniChapter 25 - Neuronal Migration of Guidepost Cells – F. Bielle, S. GarelChapter 26 - Neuronal Migration Disorders – J.J. LoTurco, A.B. Booker

III: SynaptogenesisChapter 27 - Molecular Composition of Developing Glutamatergic Synapses – S.L. Barrow, A.K. McAllisterChapter 28 - In Vivo Imaging of Synaptogenesis – M. Munz, E.S. RuthazerChapter 29 - Genetic Analysis of Synaptogenesis – C.S. Lu, D. Van VactorChapter 30 - Activity-Regulated Genes and Synaptic Plasticity – J.H. Leslie, E. NediviChapter 31 - New Imaging Tools to Study Synaptogenesis – S.J. Le Marchand, M.B. DalvaChapter 32 - Wnt Signaling – P.C. SalinasChapter 33 - Neurotrophins and Synaptogenesis, 39-658, F. Jeanneteau, M.V. ChaoChapter 34 - Ephrins and Eph Receptors – Synaptogenesis and Synaptic Function – A. Filosa, R. leinChapter 35 - Neuroligins and Neurexins – D. Schreiner, P. ScheiffeleChapter 36 - Circuit Assembly in the Developing Vertebrate Retina – T. Yoshimatsu, S.C. Suzuki, R.O.L. WongChapter 37 - Synaptogenesis in the Adult CNS – Neocortical Plasticity – R. Eavri, E. NediviChapter 38 - Synaptogenesis in the Adult CNS – Hippocampus – C. Zhao, N. Toni, F.H. GageChapter 39 - Synaptogenesis in the Adult CNS–Olfactory System – A. MizrahiChapter 40 - Synaptogenesis and Recovery from Cortical Trauma – R.J. Nudo, D. McNeal

IV: Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns; Chapter 41 - GABA: A Multifacet Device that Exerts a Crucial Role in Brain Development – Y. Ben-AriChapter 42 - Lessons from Zebrafish: Ion Channels Guide Neuronal Development –T.C. Martin, A.B. RiberaChapter 43 - Regulation of AMPA-Type Glutamate Receptor Trafficking – Boekhoorn, C.C. HoogenraadChapter 44 - Pre- and Postsynaptic Assembly and Maturation: Principal Mechanisms and Coordination – S.J. Sigrist, C. WichmannChapter 45 - Cajal–Retzius and Subplate Cells: Transient Cortical Neurons and Circuits – H.J. LuhmannChapter 46 - Chloride Homeodynamics Underlying Pathogenic Modal Shifts of GABA Actions – A. FukudaChapter 47 - GABAergic Signaling at Newborn Mossy Fiber–CA3 Synapses: Short- and Long-Term Activity-Dependent Plasticity Processes – E. CherubiniChapter 48 - BDNF and the Plasticity of Brain Networks During Maturation – J.-L. GaiarsaChapter 49 - Retinal Waves: Underlying Cellular Mechanisms and Theoretical Considerations – E. Sernagor, M.H. HennigChapter 50 - Multimodal GABAA Receptor Functions on Cell Development – A. Fukuda, Y. Nakanishi, T. umada, T. FurukawaChapter 51 - Retinal Waves and their Role in Visual System Development – M.B. Feller, D. erschensteinerChapter 52 - The Maturation of Firing Properties of Forebrain GABAergic Interneurons – B.W. Okaty, S.B. NelsonChapter 53 - Multiple Roles of CC2 in the Developing Brain – P. Uvarov, O. Llano, A. Ludwig, M.S. Airaksinen, C. RiveraChapter 54 - NKCC1 and Brain Maturation – C.K. Pfeffer, C.A. HübnerChapter 55 - Maturation of Inhibitory Synaptic Transmission in the Spinal Cord: Role of the Brain Stem and Contribution to the Development of Motor Patterns – L. VinayChapter 56 - Calcium Signals Regulate Neurotransmitter Phenotype – M. Demarque, N.C. Spitzer