Role of Capsaicin in Oxidative Stress and Cancer
Seiten
2013
|
2013 ed.
Springer (Verlag)
978-94-007-6316-6 (ISBN)
Springer (Verlag)
978-94-007-6316-6 (ISBN)
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; involvement of mitochondrial respiratory chain in the production of ROS; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
Preface.- Role of capsaicin in cancer prevention.- Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor cells.- Role of capsaicin in prostate cancer.- Capsaicin and the urinary bladder.- Inhibition of pancreatitis and carcinogenesis by capsaicin.- Cytochrome P450-dependent modification of capsaicinoids: pharmacological inactivation and bioactivation mechanisms.- The cancer suppressing and promoting actions of capsaicin.- Oxidative stress by capsaicin in cancer.
| Erscheint lt. Verlag | 7.5.2013 |
|---|---|
| Reihe/Serie | Diet and Cancer ; 3 |
| Zusatzinfo | IX, 178 p. |
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Schulbuch / Wörterbuch |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Schlagworte | Cancer • Capsaicin • Oxidative stress • prevention • therapy |
| ISBN-10 | 94-007-6316-6 / 9400763166 |
| ISBN-13 | 978-94-007-6316-6 / 9789400763166 |
| Zustand | Neuware |
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