Translational Stem Cell Research

PREFACE.- BIOSKETCHES.- SECTION I: TRANSLATIONAL STEM CELL RESEARCH: WHAT IS POSSIBLE TODAY AND WHAT STILL REMAINS TO BE ACHIEVED?- Chapter 1. Towards clinical application of stem cells in neurodegenerative disorders (Olle Lindvall and Zaal Kokaia).- Chapter 2. Treating cardiac disorders with stem cells (Christine Mummery).- Chapter 3. Treating diabetes (Mattias Hansson and Ole D. Madsen).- Chapter 4. Treating oncologic diseases (Peter W. Andrews).- Chapter 5. Clinical application of autologous epithelial stem cells in disorders of squamous epithelia (Nicolas Grasset and Yann Barrandon).- Chapter 6. Towards a cell therapy for Muscular Dystrophy: technical and ethical issues (Giulio Cossu).- Chapter 7. Towards modelling and therapy of genetic diseases using pluripotent stem cells (Petr Dvorak).- Chapter 8. Therapeutic possibilities of induced pluripotent stem cells (Harold Ayetey).- Chapter 9. Industrial applications of stem cells (Oliver Brüstle, Michael Rossbach and Manal Bosnali).- Chapter 10. The obstacles on the road to clinical applications of stem cell-based therapies: What has been done to overcome these obstacles and what remains to be done? (Outi Hovatta).- SECTION II. TRANSLATING STEM CELL RESEARCH KNOWLEDGE FROM BENCH TO BEDSIDE: ETHICAL ISSUES.- Chapter 11. Animal use in translational stem cell research and treatment development: Ethical issues (Kate Millar).- Chapter 12. Ethical aspects of stem cell-based clinical translation: research, innovation, and delivering unproven interventions (Jeremy Sugarman and Doug Sipp).- Chapter 13. Translational stem cell research in pediatrics: Ethical issues (Michael Fuchs).- Chapter 14. Experimental stem cell-based therapy in pediatrics: A fictional case study (Kristina Hug and Anders Castor).- SECTION III: CREATION OF HUMAN-ANIMAL ENTITIES FOR TRANSLATIONAL STEM CELL RESEARCH: SCIENTIFIC, ETHICAL AND REGULATORY CHALLENGES.- Chapter 15. Creation of human-animal entities for translational stem cell research:Scientific explanation of issues that are often confused (Neville Cobbe and Val Wilson).- Chapter 16. Creation of human-animal entities for translational stem cell research: Ethical issues (Gisela Badura-Lotter and Marcus Duewell).- Chapter 17. Chimeras + hybrids = chimbrids: Legal aspects (Jochen Taupitz).- SECTION IV: STEM CELL BANKING FOR TRANSLATIONAL STEM CELL RESEARCH OR STEM CELL-BASED THERAPIES.- Chapter 18. Stem cell banks: Reality, roles and challenges (Glyn Stacey).- Chapter 19. Broad consent (Linus Broström and Mats Johansson).- Chapter 20. Banks, repositories and registries of stem cell lines: The challenges to legal regulation (Mette Hartlev).- SECTION V: TRANSLATIONAL STEM CELL RESEARCH AND COMMERCIAL FUNDING.- Chapter 21. Proprietary interests and collaboration in stem cell science: Avoiding anticommons, countering canalization (Matthew Herder).- SECTION VI: PATENTING OF HUMAN STEM CELL-BASED INVENTIONS: SCIENTIFIC, ETHICAL AND REGULATORY ISSUES.- Chapter 22. Legal problems raised by patents on human stem cell-based inventions (Paul L.C. Torremans).- Chapter 23. Patenting of human stem cell-based inventions: Can there be technological solutions to a moral dilemma? (Aliki Nichogiannopoulou).- Chapter 24. Patenting of human stem cell-based inventions: Ethical issues including and beyond the morality clause (Göran Hermerén).- SECTION VII: FROM GENERAL PUBLIC TO RESEARCHERS, AND VICE VERSA: COMMUNICATION ISSUES IN TRANSLATIONAL STEM CELL RESEARCH.- Chapter 25. Ethical, legal and social implications of translational stem cell research: Effects of commercialisation on public opinion and trust of stem cell research (Ubaka Ogbogu and Amy Zarzeczny).- Chapter 26. Patients’ organisations and their opinions: How much have they been taken into consideration when regulating stem cell research? (Mary Baker and Philip Watson).- Chapter 27. Communicating translational stem cell research to the general public: Challenges and suggestions (Sébastien Duprat).-SECTION VIII: TRANSLATIONAL STEM CELL RESEARCH AND ITS PSYCHOLOGICAL IMPLICATIONS.- Chapter 28. Psychosocial and cultural factors affecting judgments and decisions about translational stem cell research (Melissa L. Finucane and Andrew E. Williams).- SECTION IX: ETHICAL EVALUATION OF TRANSLATIONAL STEM CELL RESEARCH PROJECTS IN RESEARCH ETHICS COMMITTEES.- Chapter 29. Ethics and uncertainty: Considerations for the design and review of translational trials involving stem cells (James Anderson and Jonathan Kimmelman).- SECTION X: LOOKING AT THE FUTURE OF TRANSLATIONAL STEM CELL RESEARCH AND STEM CELL-BASED THERAPEUTIC APPLICATIONS: RISKS, LONG-TERM EFFECTS AND PRIORITY SETTING.- Chapter 30. Unruhe und Ungeweissenheit – Stem cells and risks (Nils-Eric Sahlin, Johannes Persson and Niklas Vareman).- Chapter 31. Looking at the future of translational stem cell research and stem cell-based therapeutic applications: Priority setting and social justice (Göran Hermerén).