Cytoskeleton and Small G Proteins

Rho Family Proteins and Regulation of the Actin Cytoskeleton.- 1 Introduction.- 2 Structure and Regulation of Rho Family Proteins.- 3 Rho Family Proteins and Growth Factor-Induced Actin Reorganization.- 4 Rho Family Proteins and Cell Adhesion.- 5 Rho Family Proteins and Cytokinesis.- 6 Other Responses Regulated by Rho Family Proteins.- 7 Conclusions.- References.- Regulation of Cytoskeleton and Cell Adhesion by Rho Targets.- 1 Introduction.- 2 Regulation of Rho Activity.- 3 Functions of Rho.- 4 Rho Targets.- 5 Functions of Rho Targets.- 6 Conclusion.- References.- Rnd Proteins: A New Family of Rho-Related Proteins That Interfere with the Assembly of Filamentous Actin Structures and Cell Adhesion.- 1 Introduction.- 2 Characterisation of Three New Members of the Rho Family.- 3 Biochemical Properties of Rndl: G-Proteins That Do Not Switch?.- 4 Expression in Tissues and Localization of Rndl in the Brain.- 5 Effects of Rndl Expression on the Formation of Actin Stress Fibers.- 6 Localization of Rndl in Swiss 3T3 Fibroblasts and Microinjected MDCK Cells.- 7 A Role for Rnd Proteins in Transformation?.- 8 Rnd Proteins and Targets of Farnesyl-Transferase Inhibitors.- 9 Conclusions.- References.- The DH Protein Family, Exchange Factors for Rho-Like GTPases.- 1 Introduction.- 2 Identification of DH Proteins, GEFs for Rho-Like GTPases.- 3 Structure and Function of DH Proteins.- 4 Cellular Functions of DH Proteins.- 5 DH Proteins in Signaling Pathways.- 6 Concluding Remarks.- References.- RhoGAPs and RhoGDIs (His)stories of Two Families.- 1 RhoGDI (GDP Dissociation Inhibitors): Who Needs Them?.- 2 GTPase Activating Proteins (GAPs) for Rho-Like GTPases: A Catalytic Module Found Within a Plethora of Multifunctional Proteins.- 3 Conclusions.- References.- Roles of PAK Family Kinases.- 1Introduction.- 2 Distribution of PAK Family Kinases.- 3 Regulation of PAK Activity.- 4 Functions of Fungal Ste20p/PAK-Like Kinases.- 5 PAKs and Phosphorylation Pathways.- 6 PAK and Cellular Transformation.- 7 Morphological Roles for PAK Downstream of Cdc42 and Rac.- 8 Activities Associated with the Various Domains of PAK.- 9 Conclusions.- References.- Rac and Cdc42 Effectors.- 1 Introduction.- 2 Effector Proteins of Rac and Cdc42.- 3 Concluding Remarks.- References.- Small GTPases of the Rho Family and Cell Transformation.- 1 Introduction.- 2 Rho Proteins and Cell Transformation.- 3 Cross-Talk Between Ras and Rho-Dependent Pathways in Cell Transformation.- 4 Signalling Pathways Downstream of Rho Proteins Involved in Cell Transformation.- 5 Rho Proteins and Apoptosis.- 6 Concluding Remarks.- References.- Rho GTP-Binding Proteins as Targets for Microbial Pathogens.- 1 Introduction.- 2 Microbial Pathogens and the Epithelial Cell Actin Cytoskeleton.- 3 Interaction of Bacterial Protein Toxins with the Rho Subfamily of GTP-Binding Proteins.- 4 Invasive Bacterial Factors and the Rho Subfamily of GTP-Binding Proteins.- References.- Rho GTPases in Development.- 1 Introduction.- 2 The Rho Family of Small GTPases.- 3 Genetic Analysis of Rho GTPases in Drosophila Development.- 4 Rho Family GTPases in C. elegans.- 5 Rho GTPase Function in Mammals.- 6 Summary.- References.- Erratum.