Transcription Factors (eBook)

Normal and Malignant Development of Blood Cells
eBook Download: PDF
2003 | 1. Auflage
640 Seiten
Wiley (Verlag)
978-0-471-46106-7 (ISBN)

Lese- und Medienproben

Transcription Factors -
Systemvoraussetzungen
269,99 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen
Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.

Katya Ravid is the editor of Transcription Factors: Normal and Malignant Development of Blood Cells, published by Wiley. Jonathan D. Licht is the editor of Transcription Factors: Normal and Malignant Development of Blood Cells, published by Wiley.

Partial table of contents: INTRODUCTORY CHAPTER.

Transcription Factors in Normal and Malignant Hematopoiesis: An Overview (K. Ravid & J. Licht).

TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES.

The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation (A. Tsang, et al.).

Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2 (S.-W. Kim & R. Shivdasani).

EKLF and the Development of the Erythroid Lineage (J. Bieker).

TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE.

CBFA2(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages (N. Speck & E. Dzierzak).

PU.1 and the Development of the Myeloid Lineage (D. Tenen).

Transcriptional Targets of the Vitamin D3 Receptor During Myeloid Cell Differentiation (V. Bromleigh, et al.).

TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE.

The Role of Ikaros-Family Genes in Lymphocyte Differentiation and Proliferation (N. Avitahl, et al.).

The Role of PU.1 in B-Lymphocyte Development and Function (S. Rao & M. Simon).

The Role of Octamer Transcription Factors in the Lymphoid System (E. Bertolino, et al.).

The Role of Early B-Cell Factor in B Lymphocyte Development (M. Sigvardsson).

LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATIONS INVOLVING GENES ENCODING TRANSCRIPTION FACTORS.

The Role of RAR and its Fusion Partners in Acute Promyelocytic Leukemia (A. Melnick & J. Licht).

The Leukemogenic Function of the Inv(16) Fusion Gene CBFB-MYH11 (P. Liu, et al.).

The TEL-AML-1 Translocation (G. Gilliland & T. Golub).

The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations (G. Blobel).

ONCOGENESIS AND HEMATOPOIESIS.

The Roles of the C-Myc and B-Myb Oncogenes in Hematopoiesis and Leukemogenesis (M. Arsura & G. Sonenshein).

SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES.

Transcription Factors Implicated in Hematopoiesis: In Vivo Studies (Y. Kaluzhny & K. Ravid).

"The researchers who work actively on these issues will find this book to be a source of discussion and references." (International Journal of Hematology, October 2001)

Erscheint lt. Verlag 4.11.2003
Sprache englisch
Themenwelt Medizinische Fachgebiete Innere Medizin Hämatologie
Naturwissenschaften Biologie Zellbiologie
Technik
Schlagworte Biowissenschaften • Cell & Molecular Biology • Hämatologie • Hämatopoese • Hämatologie • Hämatopoese • Hematology • Life Sciences • Medical Science • Medizin • Transkriptionsfaktor • Zell- u. Molekularbiologie
ISBN-10 0-471-46106-7 / 0471461067
ISBN-13 978-0-471-46106-7 / 9780471461067
Haben Sie eine Frage zum Produkt?
PDFPDF (Adobe DRM)
Größe: 7,0 MB

Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine Adobe-ID und die Software Adobe Digital Editions (kostenlos). Von der Benutzung der OverDrive Media Console raten wir Ihnen ab. Erfahrungsgemäß treten hier gehäuft Probleme mit dem Adobe DRM auf.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine Adobe-ID sowie eine kostenlose App.
Geräteliste und zusätzliche Hinweise

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich

von James D. Brierley; Hisao Asamura; Elizabeth Van Eycken …

eBook Download (2023)
Wiley-VCH (Verlag)
84,99