Pharmacoresistance in Epilepsy

Pharmacoresistance and Epilepsy.- Genes involved in pharmacoresistant epilepsy.- Pathological oscillations in the pharmacoresistant epileptic brain.- Molecular mechanisms of pharmacoresistant epilepsy.- Modifications in the seizures susceptibility by excitotoxic neuronal damage and its possible relationship with the pharmacoresistance.- Intracellular pathways associated with neuronal survival and death in epilepsy.- The role of JNK pathway in the process of excitotoxicity induced by epilepsy and neurodegeneration.- Proteomics-based strategy to identify biomarkers and pharmacological targets in temporal lobe epilepsy.- Abnormalities of GABA system and human pharmacoresistant epilepsy.- Pharmacoresistant epilepsy and immune system.- Contribution of the antiepileptic drug administration regime in the development and/or establishment of pharmacoresistant epilepsy.- Experimental models to study pharmacoresistance in epilepsy.- Resistance to epileptogenesis in the Neotropical rodent Proechimys.- On the development of new antiepileptic drugs for the treatment of pharmacoresistant epilepsy – Different approaches to different hypothesis.- Modulating P-glycoprotein regulation as a therapeutic strategy for pharmacoresistant epilepsy.- Vagus Nerve Stimulation for Intractable Seizures.- The role of neuromodulation in the treatment of refractory epilepsy.- Transcranial magnetic stimulation and refractory partial epilepsy.- Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity.- Physical exercise as a strategy to reduce seizure susceptibility.