Decoding the Genomic Control of Immune Reactions (eBook)
232 Seiten
Wiley (Verlag)
978-0-470-06211-1 (ISBN)
Specific problems addressed include the following:
- What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance?
- Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?
- Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?
Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance? Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues? Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses? Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Decoding the Genomic Control of Immune Reactions 1
Contents 7
Chair’s introduction 13
Transcriptional regulatory networks in macrophages 14
DISCUSSION 30
The RIKEN mouse transcriptome: lessons learned and implications for the regulation of immune reactions 37
DISCUSSION 46
Molecular pathways for lymphangiogenesis and their role in human disease 50
DISCUSSION 56
GENERAL DISCUSSION I 62
Specifying the patterns of immune cell migration 66
DISCUSSION 73
Human monogenic disorders that confer predisposition to specific infections 77
DISCUSSION 85
The genetic control of susceptibility to Mycobacterium tuberculosis 91
DISCUSSION 101
Th2 lymphoproliferative disorders resulting from defective LAT signalosomes 105
DISCUSSION 112
Genetic analysis of systemic autoimmunity 115
DISCUSSION 132
Genetic resistance to smallpox: lessons from mousepox 141
DISCUSSION 148
The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes 153
DISCUSSION 165
Genetic control of host–pathogen interactions in mice 168
DISCUSSION 177
Mycobacterium tuberculosis and its ability to resist immunity 181
DISCUSSION 189
Systems genetics: the next generation in genetics research? 193
DISCUSSION 200
Regulation of the immune system in metazoan parasite infections 204
DISCUSSION 216
Closing remarks 220
Contributor Index 222
Subject Index 224
"...useful to...researchers and clinicians with a particular interest in pathways of regulation." (Doody's Health Services)
Erscheint lt. Verlag | 4.4.2007 |
---|---|
Reihe/Serie | Novartis Foundation Symposium |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
Schlagworte | Bioinformatics & Computational Biology • Bioinformatik • Bioinformatik u. Computersimulationen in der Biowissenschaften • Biowissenschaften • Genetics • Genetik • Genomforschung u. Proteomik • genomics • Genomics & Proteomics • Immunologie • Life Sciences • Microbiology & Virology • Mikrobiologie u. Virologie |
ISBN-10 | 0-470-06211-8 / 0470062118 |
ISBN-13 | 978-0-470-06211-1 / 9780470062111 |
Haben Sie eine Frage zum Produkt? |
![PDF](/img/icon_pdf_big.jpg)
Größe: 8,6 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Zusätzliches Feature: Online Lesen
Dieses eBook können Sie zusätzlich zum Download auch online im Webbrowser lesen.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich