Mast Cells and Basophils (eBook)

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MAST CELLS AND BASOPHILS: DEVELOPMENT, ACTIVATION AND ROLES IN ALLERGIC/AUTOIMMUNE DISEASE 3
Contents 9
Participants 13
Chair’s introduction 17
MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells 20
Discussion 27
Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells 31
Discussion 40
The role of Src family kinases in mast cell effector function 55
Discussion 63
RasGRP4 in mast-cell signalling and disease susceptibility 70
Discussion 84
Regulation of mast cell secretory response to the type I Fce receptor: inhibitory elements and desensitisation 94
Discussion 105
General discussion I 111
IgE regulation of mast cell survival and function 116
Discussion 124
RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation 131
Discussion 140
Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FceRI- and/or CCR1-engaged mast cells using protein chip technology 147
Discussion 156
General discussion II 214
The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract 168
Discussion 177
The mast cell and the cysteinyl leukotrienes 182
Discussion 192
Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes 195
Discussion 203
The involvement of Bcl-2 in mast cell apoptosis 207
Discussion 211
General discussion III 214
Mast cells in autoantibody responses and arthritis 216
Discussion 226
MASTering the immune response: mast cells in autoimmunity 231
Discussion 241
Mastocytosis 248
Discussion 258
Index of contributors 266
Subject index 268

"This is an excellent resource for clinicians or basic scientists with an interest in mast cells and related diseases." (Doody's Health Services)