Brain Energetics and Neuronal Activity (eBook)

Robert Gerson Shulman is a biophysicist and Sterling Professor Emeritus of Molecular Biophysics and Biochemistry and a Senior Research Scientist at the Department Diagnostic Radiology at Yale University. Douglas L. Rothman is the editor of Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine, published by Wiley.

Brain Energetics and Neuronal Activity 3
Contents 7
Contributors 9
Foreword 11
Section A: Background 15
1 Introduction 17
2 Energy Metabolism in Neural Tissues in vivo at Rest and in Functionally Altered States 25
3 Techniques–MRS, fMRI, (13)C NMR, Indirect Detection of (13)C 45
4 Metabolic Modeling Analysis of Brain Metabolism 67
Section B: Neuroenergetics and Activity 87
5 Cerebral Energetics and Neurotransmitter Fluxes 89
6 NMR Studies of the Metabolism and Energetics of GABA Neurotransmitter Pathways 113
7 Neural Energy Consumption and the Representation of Mental Events 125
8 Imaging Cerebral Metabolic Rate of Oxygen Consumption (CMRO(2)) using (17)O NMR Approach at Ultrahigh Field 139
9 Deriving Changes in CMR(O2) from Calibrated fMRI 161
10 Relationship between CMR(O2) and Neuronal Activity 187
Section C: Clinical Beginnings 209
11 NMR Studies of Bioenergetic Impairment in Human Epilepsy 211
12 MRS Studies of the Role of Altered Glutamate and GABA Neurotransmitter Metabolism in the Pathophysiology of Epilepsy 229
13 The Role of Altered Energetics of Neurotransmitter Systems in Psychiatric Disease 253
Section D: Brain and Mind 271
14 Long-term Memory: Do Incremental Signals Reflect Engagement of Cognitive Processes? 273
15 Using fMRI to Study the Mind and Brain 293
16 Brain and Mind: an NMR Perspective 309
17 The Role of the NMR Baseline Signal in the Study of Consciousness: the Restless Brain 325
Index 329

"...high quality scientific data and...consistent formatting...I would recommend this book as a reference for those in the academic field who work closely with MR physicists..." (AuntMinnie.com, May 24, 2006)