Pharmacogenetics and Individualized Therapy

ANKE-HILSE MAITLAND-van der ZEE, PhD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands. ANN K. DALY, PhD, is Professor of Pharmacogenetics at Newcastle University, UK.

PREFACE vii CONTRIBUTORS ix 1. Pharmacogenetics: A Historical Perspective 1 Ann K. Daly PART I PHARMACOGENETICS: RELATIONSHIP TO PHARMACOKINETICS AND PHARMACODYNAMICS 2. Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes 15 Vita Dolz!an 3. Pharmacogenetics of Phase II Drug Metabolizing Enzymes 81 Ingolf Cascorbi 4. Pharmacogenetics of Drug Transporters 101 Henriette E. Meyer zu Schwabedissen, Markus Grube, and Heyo K. Kroemer 5. Pharmacogenetics of Drug Targets 149 Ann K. Daly and Maria Arranz PART II PHARMACOGENETICS: THERAPEUTIC AREAS 6. Cardiovascular Pharmacogenetics 185 Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel, and Anke-Hilse Maitland-van der Zee 7. Pharmacogenetics in Psychiatry 215 Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison, and Ann K. Daly 8. Pharmacogenetics in Cancer 251 Sharon Marsh 9. Pharmacogenetics of Asthma and COPD 271 Ellen S. Koster, Jan A. M. Raaijmakers, Anke-Hilse Maitland-van der Zee, and Gerard H. Koppelman 10. Pharmacogenetics of Adverse Drug Reactions 295 Ann K. Daly, Martin Armstrong, and Munir Pirmohamed 11. Pharmacogenomics of Inflammatory Bowel Diseases 323 Alexander Teml, Susanne Karner, Elke Schaeffeler, and Matthias Schwab 12. Pharmacogenetics of Pain Medication 353 Jo¨rn Lo¨tsch PART III PHARMACOGENETICS: IMPLEMENTATION IN CLINICAL PRACTICE 13. Ethical and Social Issues in Pharmacogenomics Testing 377 Susanne Vijverberg, Toine Pieters, and Martina Cornel PART IV DEVELOPMENTS IN PHARMACOGENETIC RESEARCH 14. High-Throughput Genotyping Technologies for Pharmacogenetics 403 Beatriz Sobrino and Angel Carracedo 15. Developments in Analyses in Pharmacogenetic Datasets 415 Alison A. Motsinger-Reif PART V PHARMACOGENETICS: INDUSTRY AND REGULATORY AFFAIRS 16. Applications of Pharmacogenetics in Pharmaceutical Research and Development 439 Daniel K. Burns and Scott S. Sundseth 17. Role of Pharmacogenetics in Registration Processes 461 Myong-Jin Kim, Issam Zineh, Shiew-Mei Huang, and Lawrence J. Lesko PART VI CONCLUSIONS 18. Pharmacogenetics: Possibilities and Pitfalls 479 Anke-Hilse Maitland-van der Zee and Ann K. Daly INDEX 485