Toxoplasma Gondii

Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.

Preface 1. The History and Life Cycle of Toxoplasma gondii 2. The Ultrastructure of Toxoplasma gondii 3. Population Structure and Epidemiology of Toxoplasma gondii 4. Toxoplasma Clinical Disease and Diagnostics 5. Ocular Disease 6. Toxoplasmosis in Wild and Domestic Animals 7. Toxoplasma Animal Models and Therapeutics 8. Biochemistry, Lipids, Glycobiology and Metabolism of Toxoplasma gondii 9. The Apicoplast and Mitochondrion of Toxoplasma gondii 10. Calcium Storage and Homeostasis in Toxoplasma gondii 11. The Parasitophorous Vacuole: an organelle for the host pathogen interface 12. Toxoplasma Secretory Organelles: Rhoptries, Micronemes and Dense Granules 13. The Cytoskelton: Structure and Motility 14. Alterations in Host Cell Biology due to Toxoplasma gondii 15. Bradyzoite Development 16. Development and Application of Classical Genetics in Toxoplasma gondii 17. Genetic Manipulation 18. Gene Regulation and Epigenomics 19. Genomic Analysis and Bioinformatics 20. Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and other Apicomplexa 21. Chemical Biology and Toxoplasma as a Model System for Drug Discovery 22. Proteomics of Toxoplasma gondii 23. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioural Consequences 24. Innate Immunity in Toxoplasma Infection 25. Adaptive Immunity and host Genetics 26. Toxoplasma gondii vaccines Epilogue: Toxoplasma as a Model Organism