Pyrrole-Imidazole Alkaloids from Marine Sponges: Structural Variation and Cytotoxicity of (-)-Dibromophakellstatin, Synthesis of Ugibohlin and Oroidin, and Studies Towards Oxocyclostylidol
Seiten
2012
|
1., Aufl.
Cuvillier, E (Verlag)
978-3-95404-228-9 (ISBN)
Cuvillier, E (Verlag)
978-3-95404-228-9 (ISBN)
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Oroidin is considered to be the biogenetic key metabolite of the pyrroleimidazole alkaloids. Several syntheses are known to date, all of which contain steps with only moderate yields. For a study on its reactivity large quantities are needed. Therefore, an improved synthesis would be beneficial. In the present work two different known routes to 8 were investigated. By following the method developed in our group (via Sonogashira coupling) several analogues arose as new products. By treating the two deaminated analogs 1 and 4 with NBS in TFA, no cyclization to the phakellin skeleton 3 took place. Instead, pyrrole oxidation occurred (Scheme 1).
Sprache | englisch |
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Einbandart | kartoniert |
Themenwelt | Naturwissenschaften ► Chemie |
Schlagworte | Organische Chemie |
ISBN-10 | 3-95404-228-2 / 3954042282 |
ISBN-13 | 978-3-95404-228-9 / 9783954042289 |
Zustand | Neuware |
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