Click Chemistry in Glycoscience: New Developments and Strategies - Zbigniew J. Witczak, Roman Bielski

Click Chemistry in Glycoscience: New Developments and Strategies

Software / Digital Media
400 Seiten
2013
John Wiley & Sons Inc (Hersteller)
978-1-118-52699-6 (ISBN)
124,24 inkl. MwSt
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The first text to focus on the application of click chemistry to glycoscience, this book discusses the therapeutic and pharmacological aspects of carbohydrate click chemistry and includes chapters on the concept's background, as well as its industrial applications in areas such as drug discovery. The book reflects the novel methodologies and strategies of this concept. Each chapter describes new approaches, ideas, consequences, and applications deriving from the introduction of click processes. This provides an essential reference for a wide range of researchers and graduate-level students.

ZBIGNIEW J. WITCZAK, PhD, is Professor in the Department of Pharmaceutical Sciences of the Nesbitt School of Pharmacy at Wilkes University. He has published over ninety research papers and holds six patents. His research focuses on carbohydrate synthons, including levoglucosenone and L-arabinose, as templates for carbohydrate-based therapeutics. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award from the ACS Division of Carbohydrate Chemistry. ROMAN BIELSKI, PhD, is Senior Scientist at Value Recovery, Inc., Partner in Cheminnolab, LLC, and Adjunct Professor in the Department of Pharmaceutical Sciences at Wilkes University. His research investigates the origin of homochirality, modification of carbohydrates, solutions to environmental issues, and sustainability. As part of his achievements, Dr. Bielski co-developed a method of enantiomers' resolution, which might have been involved in prebiotic homochirality, since it would not require the use of chiral compounds.

Foreword Preface Contributors List of Abbreviations Click chemistry strategies and decoupling Chapter 1. Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling Roman Bielski, Zbigniew J. Witczak Thio-click chemistry of carbohydrates Chapter 2. Thio-click Chemistry Overviews and Perspectives Zbigniew J. Witczak Chapter 3. Free-Radical Photoinduced Thiol-Ene and Thiol-Yne Coupling as Click Processes for Glycoconjugation Alessandro Dondoni, Alberto Marra. Carbohydrate click chemistry for novel synthetic targets Chapter 4. The Development and Application of Clickable Lipid Analogues for Elucidating Lipid Function Michael Best Chapter 5. Clicking Sugars onto Sugars: Oligosaccharide Analogues and Glycoclusters on Carbohydrate Scaffolds Maria Laura Uhrig, Jose Kovensky Chapter 6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomatrials and Glycosurfaces Carmen Ortiz Mellet, Alejandro Mendez-Ardoy, Jose Manuel Garcia Fernandez Chapter 7. Toward Imaging Glycotools by Click Coupling Yves Chapleur, Christine Vala, Francoise Chretien, Sandrine Lamande-Langle Chapter 8 Bioorthogonal Reactions for Labeling Glycoconjugates Frederic Friscourt, Geert-Jan Boons Chapter 9. Sweet Sucrose Macrocycles via Click Chemistry Route Mykhaylo A. Potopnyk, Slawomir Jarosz Carbohydrate click chemistry in biomedical sciences Chapter 10. Neoglycoprotein Synthesis using Copper-catalyzed Azide-Alkyne Click reaction and Native Chemical Ligation Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B.H. Kent Margaret A. Brimble Chapter 11. Click-modified Cyclodextrin for Biomedical Application Zhenshan Jia, Rakesh K. Singh, Dong Wang Chapter 12. Triazolyl Glycoconjugates in Medicinal Chemistry Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha Vinod Kumar Tiwari Chapter 13. Click Chemistry Applied to Carbohydrate-based Drug Discovery Vannessa Leiria Campo, Ivone Carvalho Index

Vorwort Derek Horton
Verlagsort New York
Sprache englisch
Maße 228 x 284 mm
Themenwelt Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie
ISBN-10 1-118-52699-6 / 1118526996
ISBN-13 978-1-118-52699-6 / 9781118526996
Zustand Neuware
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