Autoantibodies and Autoimmunity (eBook)

Kenneth Michael Pollard is Associate Professor at the W.M. Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, California, USA. He gained his doctorate from the University of Sydney, Australia, and worked at the Sutton Rheumatism Research Laboratory, St. Leonards, Australia before joining The Scripps. Among others, he is a member of the American Society for Microbiology, the Australian Society of Immunology, the RNA Society, the American Association of Immunologists, and the Society of Toxicology. A frequent invited speaker at international conferences, Professor Pollard has also been on six NIH Advisory Committees. Alongside being a reviewer for 13 journals, he has over 50 publications to his name. K. Michael Pollard obtained his PhD from the University of Sydney, Australia. The majority of his career has been spent at The Scripps Research Institute in La Jolla, California, USA where he has been a faculty member since 1992. His publications include over 40 research articles as well as a number of book chapters and reviews. His major research interests include mechanisms involved in the initiation of autoimmunity and how the interplay between genetics and environment influences the expression of systemic autoimmune diseases. He and his wife Miranda, a veterinarian, share their lives with three Standard Poodles, and four cats named after famous Irishmen.

Introduction
Prefatory Chapter: The Importance of the Autoantibody-Defined Epitope
AUTOIMMUNITY
Self/Non-Self Recognition
Central and Peripheral Tolerance
T-B Cell Interactions in Autoimmunity
Cell Death and Autoimmunity
Self Antigen Modification and Autoimmunity
AUTOANTIBODIES AS DIAGNOSTIC MARKERS
Detection of Autoantibodies
Synthetic Peptides for the Analysis of B-Cell Epitopes in Autoantigens
Autoantibodies and Systemic Autoimmune Diseases
Autoantibodies in Systemic Lupus Erythematosus
Autoantibodies in Rheumatoid Arthritis
Autoantibodies and Organ Specific Autoimmune Diseases
Autoantibodies in Autoimmune Thyroid Disease
Autoantibodies in Diabetes
AUTOANTIBODIES AS MOLECULAR AND CELLULAR PROBES
Autoantibody Recognition of Cellular and Subcellular Organelles
Autoantibody Recognition of Macromolecular Structures and Their Subunits
Autoantibodies and the Cloning and Characterization of Cellular Constituents
Tolerance and Immunity to the Ro/La RNP Complex
Autoantibody Recognition of Functional Sites
AUTOANTIBODIES IN EXPERIMENTAL MODELS OF AUTOIMMUNITY
Novel Mechanisms of Autoantibody Induction and Pathogenesis in Experimental Autoimmunity
Environmental Factors that Contribute to Autoimmunity
Spontaneous Models of Autoimmunity
Genetic Manipulation
Perspectives

"This is the first book to address all aspects of the biology of autoantibodies in a single volume ... With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists."
Clinical Laboratory

"Die druchtechnischen Arbeiten sind sauber ausgeführt."
BDI aktuell

"Pollard ist gelungen, eine Gruppe hochrangiger Forscher aus der ganzen Welt dazu zu bringen, ein umfassendes Bild über die Biologie der Autoantikörper zu generieren. ... Es ist erstaunlich, wieviel Wissen die Autoren zu dem Thema zusammengetragen haben und wieviel doch am Phänomen der Autoimmunität nach wie vor unklar bleibt. Auf jeden Fall ist es dem Herausgeber und seinen Coautoren gelungen, ein sehr spannendes Buch über die Autoantikörper und Autoimmunität zu verfassen."
Pharmazie in unserer Zeit

"Das vorliegende Buch ist nicht zuletzt auch aufgrund seines Umfanges ein Nachschlagewerk für Experten und Studierende."
Umwelt & Gesundheit