DNA Repair

Fritz Eckstein, David M.J. Lilley (Herausgeber)

Buch | Softcover

XI, 317 Seiten

2012 | 1. Softcover reprint of the original 1st ed. 1998
Springer Berlin (Verlag)
978-3-642-48772-9 (ISBN)

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DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. Cells therefore put a great deal of resources into repairing any damage to this precious store. Mechanisms of DNA repair vary greatly in their level of complexity, from specific reversal mechanisms that involve a single protein, to sequential pathways that require many enzymes. But at the heart of all these mechanisms lie proteins that recognize damage to DNA, raising important questions about how damaged DNA may be distinguished. These recognition processes are now finally yielding their secrets to structural analysis. This volume focuses on DNA repair, with an emphasis on structural data where available.

Repair of Alkylated DNA by the E. coli Ada Protein.- Structural Phylogenetics of DNA Base Excision Repair.- Protein Interactions in Mammalian Pathways of DNA Base Excision Repair.- Poly(ADP-Ribose) Polymerase Is Required for Maintenance of Genomic Integrity During Base Excision Repair.- Functional Domains of the E. coli UvrABC Proteins in Nucleotide Excision Repair.- Nucleotide Excision Repair in Yeast: Recent Progress and Implications.- Nucleotide Excision Repair in Man.- Transcription-Coupled and Global Genome Nucleotide Excision Repair.- DNA Mismatch Repair.- Eukaryotic Mismatch Repair.- Conflicting Roles of Mismatch and Nucleotide Excision Repair in Cellular Susceptibility to Anticancer Drugs.- Crystallographic Studies of Proteins Involved in Recombinational Repair and Excision Repair.- Eukaryotic DNA Ligases and DNA Repair.

Erscheint lt. Verlag	19.4.2012
Reihe/Serie	Nucleic Acids and Molecular Biology
Zusatzinfo	XI, 317 p. 19 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	510 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Base • base exision repair • Cell • DNA • DNA repair • Enzyme • enzymes • Genetics • Genome • Nucleotide • nucleotide excision repair • Protein • proteins • transcription
ISBN-10	3-642-48772-6 / 3642487726
ISBN-13	978-3-642-48772-9 / 9783642487729
Zustand	Neuware