Microtubules

From the Introduction to the First Edition.- Acknowledgments.- 1 Historical Background.- 1.1 Micro tubules (MT).- 1.2 Colchicine: A Specific MT Poison.- 1.3 Other MT Poisons.- 1.4 Action of Physical Agents.- 1.5 Conclusion.- References.- 2 Structure and Chemistry of Microtubules.- 2.1 Introduction.- 2.2 General Morphology of MT.- 2.3 Structure of MT.- 2.4 Biochemistry of MT and Associated Proteins.- 2.5 Assembly and Disassembly of MT in Vitro.- 2.6 Summary.- References.- 3 General Physiology of Tubulins and Microtubules.- 3.1 Introduction.- 3.2 Tubulin Synthesis and Its Regulation.- 3.3 Assembly of MT in Vivo.- 3.4 Relations of MT with Other Cell Structures and Organelles.- 3.5 Relations with Viruses and Endocellular Parasites.- 3.6 Extracellular MT.- References.- 4 Complex Microtubule Assemblies: Axonemes, Centrioles, Basal Bodies, Cilia, and Flagella.- 4.1 Introduction.- 4.2 Axonemes.- 4.3 Centrioles.- 4.4 Cilia and Flagella. Introduction.- 4.5 Basal Bodies.- 4.6 Regeneration of Cilia and Ciliogenesis.- 4.7 Atypical and Pathological Cilia.- References.- 5 Microtubule Poisons.- 5.1 Introduction.- 5.2 Colchicine and Colchicine Derivatives.- 5.3 The Catharanthus (Vinca) Alkaloids.- 5.4 Podophyllotoxin and Related Molecules.- 5.5 Sulfhydryl Reagents.- 5.6 The Benzimidazole Derivatives.- 5.7 Griseofulvin.- 5.8 Anesthetic Drugs.- 5.9 Other MT Poisons.- 5.10 Taxol: An Agent That Favorizes MT Assembly.- 5.11 Action of Physical Agents and Heavy Water.- References.- 6 Cell Shape.- 6.1 Introduction.- 6.2 Disk-Shaped Blood Cells.- 6.3 Nuclear and Cytoplasmic Shaping in Spermatogenesis.- 6.4 Other Cytoskeletal Functions of MT in Metazoa.- 6.5 Egg Differentiation and Embryonic Growth.- 6.6 Cell Shape in Plants.- 6.7 Cell Shape in Protozoa.- 6.8 MT with Mechanical Functions.- References.- 7 Cell Movement.- 7.1 Introduction.- 7.2 Intracellular Displacements and Motion.- 7.3 The Movement of Pigment Granules.- 7.4 Movements of Cell Membranes and "Capping".- 7.5 Cell Motility and Locomotion.- 7.6 Ciliary Movements.- References.- 8 Secretion.- 8.1 Introduction.- 8.2 Endocrine Secretions.- 8.3 Exocrine Secretions.- 8.4 Leukocytes and Related Cells.- 8.5 Other Cell Activities Related to Secretion.- 8.6 Conclusions.- References.- 9 Neurotubules and Neuroplasmic Transport.- 9.1 Introduction.- 9.2 General Properties of Nerve MT.- 9.3 Relations of MT with Synaptic Vesicles.- 9.4 Microtubules and Nerve Cells Shape.- 9.5 Experimental Changes of Neuronal MT.- 9.6 Neuroplasmic Transport and MT.- 9.7 Role of MT in Axoplasmic Transport.- 9.8 Theories of Neuroplasmic Transport.- 9.9 MT and Sensory Cells.- References.- 10 Microtubules and Mitosis.- 10.1 Introduction.- 10.2 Some Aspects of the Possible Evolution of Mitosis.- 10.3 Some Types of Mitosis.- 10.4 Methods of Study.- 10.5 MT and Mitotic Movements.- 10.6 Other Proteins Associated with Mitotic MT.- 10.7 The Action of MT Poisons on Mitosis.- 10.8 The Action of Physical Factors on Mitosis.- 10.9 Microtubules and the Mechanisms of Mitosis.- 10.10 Conclusions.- References.- 11 MT and MT Poisons in Pathology and Medicine.- 11.1 Introduction.- 11.2 Pathology of MT Structures.- 11.3 Therapeutic Uses of MT Poisons.- 11.4 The Toxicity of the Vinca (Catharanthus) Alkaloids.- 11.5 Toxicity of MT Poisons in Cancer Chemotherapy 433 References.- 12 Post-Script and Outlook.- 12.1 Unity and Diversity.- 12.2 Microtubule-Associated Proteins (MAPs).- 12.3 Assembly and Disassembly.- 12.4 Microtubule Poisons.- 12.5 Non-Microtubular Tubulin.- 12.6 Micro tubules and Movement.- 12.7 Micro tubules and Cell Shape.- 12.8 Microtubules and Evolution.- References.- Addenda Some of the Most Interesting Papers Published in 1983 and Early in 1984.- Recent Books and Reviews on Microtubules and Related Subjects.